Evidence map›Paper›PMID 40572534›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis of New DltA Inhibitors and Their Application as Adjuvant Antibiotics to Re-Sensitize Methicillin-Resistant

David Leparfait, Alexandre Mahé, Xiao Feng, Delphine Coupri, Fabien Le Cavelier, Nicolas Verneuil, Emmanuel Pfund, Aurélie Budin-Verneuil, Thierry Lequeux

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural Insights into theBiomolecules · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David LeparfaitENSICAEN, Université de Caen Normandie, Université de Rouen Normandie, INSA Rouen Normandie, CNRS, Institut CARMeN UMR 6064, 14050 Caen, France.ORCID 0009-0009-0653-0065
Alexandre MahéCBSA UR 4312, Université de Caen Normandie, 14000 Caen, France.ORCID 0009-0005-4487-9015
Xiao FengENSICAEN, Université de Caen Normandie, Université de Rouen Normandie, INSA Rouen Normandie, CNRS, Institut CARMeN UMR 6064, 14050 Caen, France.
Delphine CoupriCBSA UR 4312, Université de Caen Normandie, 14000 Caen, France.
Fabien Le CavelierENSICAEN, Université de Caen Normandie, Université de Rouen Normandie, INSA Rouen Normandie, CNRS, Institut CARMeN UMR 6064, 14050 Caen, France.
Nicolas VerneuilCBSA UR 4312, Université de Caen Normandie, 14000 Caen, France.
Emmanuel PfundENSICAEN, Université de Caen Normandie, Université de Rouen Normandie, INSA Rouen Normandie, CNRS, Institut CARMeN UMR 6064, 14050 Caen, France.ORCID 0000-0003-1896-0109
Aurélie Budin-VerneuilCBSA UR 4312, Université de Caen Normandie, 14000 Caen, France.ORCID 0000-0002-1173-251X
Thierry LequeuxENSICAEN, Université de Caen Normandie, Université de Rouen Normandie, INSA Rouen Normandie, CNRS, Institut CARMeN UMR 6064, 14050 Caen, France.ORCID 0000-0003-3783-4458

Funding

Agence Nationale de la Recherche ANR-19-CE18-0008 and ANR-11-LABX-0029
6 · The paper itself

Abstract

The synthesis of a new acyclic and cyclic series of D-Ala-AMP analogues was reported. Chemical modifications were introduced on the carbohydrate, the sulfamate linker, and/or the amino-acid

Indexed as

Anti-Bacterial AgentsBacterial ProteinsMethicillin-Resistant Staphylococcus aureusAnimalsMicrobial Sensitivity TestsStaphylococcal InfectionsStructure-Activity RelationshipAnti-Bacterial AgentsBacterial Proteinsantibiotic resistanceDltA inhibitornucleoside analogs

Identifiers

PMID40572534
PMCPMC12196251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.