Design and Optimization of a Tapered Magnetic Soft Continuum Robot for Enhanced Navigation in Cerebral Vasculature.

Magnetic soft continuum robots (MSCRs) have broad application advantages in vascular intervention; however, current MSCRs still face challenges in navigating the narrower and tortuous structure of the cerebral vasculature. To address this challenge, we propose a tapered MSCR (T-MSCR), which is designed to facilitate smooth navigation through microvascular structures via its miniature tip. Specifically, to optimize its bending ability, we combine the Gray Wolf Optimizer (GWO) with the Euler-Bernoulli beam theory and introduce a Discrete GWO (DGWO) approach to optimize the distribution of magnetic particles within the T-MSCR. We then demonstrate the optimization process of the T-MSCR's bending ability, comparing and analyzing its deflection angle and deformation characteristics, highlighting its capability to enter microvasculars. Furthermore, we demonstrate the magnetic steering and path selection capabilities of T-MSCR in a two-dimensional vascular model and its navigation performance in real-scale human vascular models. Finally, biocompatibility tests confirm that T-MSCR exhibits no toxicity to human cells, thereby laying a solid foundation for its clinical application. The proposed T-MSCR design and optimization are expected to provide a more efficient and feasible solution for future cerebrovascular interventions.