Evidence map›Paper›PMID 40572289›Full record

ArticleMicroorganisms2025

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates.

H M Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

H M Adnan HameedState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.
Cuiting FangState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.ORCID 0000-0002-8045-3098
Zhiyong LiuState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.
Yamin GaoState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.ORCID 0000-0003-4131-3444
Shuai WangState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.
Xinwen ChenGuangzhou National Laboratory, Guangzhou 510005, China.ORCID 0000-0002-4052-8155
Nanshan ZhongGuangzhou National Laboratory, Guangzhou 510005, China.
Htin Lin AungChina-New Zealand Joint Laboratory of Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Jinxing HuState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.
Tianyu ZhangState Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou Chest Hospital, Guangzhou 510530, China.ORCID 0000-0001-5647-6014

Funding

Guangzhou Key Medical Disciplines 2025-2027Guangzhou Science and Technology Plan-Youth Doctoral "Sail" Project 2024A04J4273National Foreign Expert Project-Foreign Young Talents Program QN2022031002LNational Key R&D Program of China 2021YFA1300904President's International Fellowship Initiative-CAS 2023VBC0015State Key Laboratory of Respiratory Diseases SKLRD-Z-202301, SKLRD-Z-202412, SKLRD-OP-202324
6 · The paper itself

Abstract

Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZA

Indexed as

clinical isolatesclpC1drug resistancemolecular diagnosisMycobacterium tuberculosispyrazinamide

Identifiers

PMID40572289
PMCPMC12196252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.