Evidence map›Paper›PMID 40572169›Full record

ArticleMicroorganisms2025

Isthmin1 Upregulation in the Intestinal Microenvironment During

Gustavo Alberto Jaimes-Ortega, Tania Angeles-Floriano, Guadalupe Rivera-Torruco, Julio Cesar Almanza-Pérez, Juan Xicohtencatl-Cortes, Eduardo Hernández-Cuellar, Oscar Medina-Contreras, Ariadnna Cruz-Córdova, Ricardo Valle-Rios

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gustavo Alberto Jaimes-OrtegaImmunology and Proteomics Research Laboratory, Children's Hospital of Mexico "Federico Gómez" (HIMFG), Mexico City 06720, Mexico.
Tania Angeles-FlorianoUniversity Research Unit UNAM-HIMFG, Research Division, School of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Guadalupe Rivera-TorrucoImmunology and Proteomics Research Laboratory, Children's Hospital of Mexico "Federico Gómez" (HIMFG), Mexico City 06720, Mexico.ORCID 0000-0003-2835-6343
Julio Cesar Almanza-PérezDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Leyes de Reforma 1A Sección, Alcaldía Iztapalapa, Ciudad de México 09310, Mexico.ORCID 0000-0002-9417-5500
Juan Xicohtencatl-CortesLaboratorio de Investigación en Bacteriología Intestinal, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.ORCID 0000-0003-2577-9973
Eduardo Hernández-CuellarLaboratorio de Biología Celular y Tisular, Departamento de Morfología, Universidad Autónoma de Aguascalientes, Aguascalientes 20100, Mexico.ORCID 0000-0002-5996-9313
Oscar Medina-ContrerasEpidemiology, Endocrinology & Nutrition Research Unit, Children's Hospital of Mexico "Federico Gomez", Mexico City 06720, Mexico.ORCID 0000-0002-4432-7780
Ariadnna Cruz-CórdovaLaboratorio de Investigación en Inmunoquímica, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
Ricardo Valle-RiosImmunology and Proteomics Research Laboratory, Children's Hospital of Mexico "Federico Gómez" (HIMFG), Mexico City 06720, Mexico.

Funding

Fondos Federales HIM SSA 1598 and 1839
6 · The paper itself

Abstract

Isthmin1 (ISM1) is a constitutively secreted cytokine produced by barrier tissues and different immune cell types. Importantly, ISM1 is also expressed by cells with a hematopoietic stem cell phenotype in the lung and plays a role during hematopoiesis. Under inflammatory conditions, ISM1 levels are also altered. Given that the intestine is one of the tissues with the highest ISM1 gene expression, in this work, we characterized the immunophenotype of ISM1-producing cells in the small intestine of uninfected or

Indexed as

hematopoietic stem cellsIsthmin1Salmonella Typhimuriumsmall intestine

Identifiers

PMID40572169
PMCPMC12195075

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.