ArticleNeurogastroenterology and motility2025
Targeting the Microbiota Reverses C-Section-Induced Effects on Intestinal Permeability, Microbiota Composition, and Amygdala Gene Expression in the Mouse.
Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundThe microbiome significantly influences the development of the gastrointestinal and immune systems. The delivery method, whether Caesarean section (CS) or vaginal birth (VB), plays a crucial role in shaping microbiota composition, with CS babies exhibiting differences. Early-life nutritional interventions using probiotics or prebiotics may help restore this imbalance in CS infants. Our study aimed to assess gut permeability in CS mice compared to VB mice and explore whether prebiotics or probiotics could mitigate any deficiencies.
methodsUsing a mouse model (NIH Swiss) for CS delivery, we measured plasma levels of a 4 kDa macromolecule (FITC) at PND7, 14, 23, and 35. We evaluated ileal gene expression of tight junction proteins, profiled intestinal microbiome composition, and examined the expression of genes involved in neurotransmitter physiology in the amygdala. Additionally, we studied the impact of administering Bifidobacterium breve in drinking water and dietary administration of GOS/FOS on these outcomes. KEY
resultsAt PND7, CS-born mice exhibited increased ileal permeability, along with reduced expression of Tjp1, Occludin, Claudin 3, and Epcam compared to VB mice. Administration of B. breve or GOS/FOS alleviated changes in Epcam expression. During the pre-weaning period, beta diversity differed between VB and CS. Post-weaning, β-diversity increased following probiotic and prebiotic intervention. Additionally, CS mice showed changes in neurotransmitter gene expression in the amygdala, which were also mitigated by B. breve or GOS/FOS. DISCUSSION: Our findings indicate that targeted microbiota-associated interventions can reverse deficits in intestinal permeability induced in CS mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.