Evidence map›Paper›PMID 40571975›Full record

Trial reportAnnals of the New York Academy of Sciences2025

Quality of life in older adults is enhanced by piano practice: Results from a randomized controlled trial.

Florian Worschech, Damien Marie, Christopher Sinke, Matthias Kliegel, Kristin Jünemann, Daniel S Scholz, Tillmann H Krüger, Clara E James, Eckart Altenmüller

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Florian WorschechInstitute of Music Physiology and Musicians' Medicine, Hanover University of Music, Drama and Media, Hanover, Germany.ORCID 0000-0001-7185-8870
Damien MarieGeneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland HES-SO, Geneva, Switzerland.
Christopher SinkeDivision of Clinical Psychology and Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.
Matthias KliegelFaculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
Kristin JünemannDivision of Clinical Psychology and Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.
Daniel S ScholzDepartment of Musicians' Health, University of Music Lübeck, Lübeck, Germany.ORCID 0000-0002-4880-7773
Tillmann H KrügerCenter for Systems Neuroscience, Hanover, Germany.
Clara E JamesGeneva Musical Minds Lab, Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland HES-SO, Geneva, Switzerland.
Eckart AltenmüllerInstitute of Music Physiology and Musicians' Medicine, Hanover University of Music, Drama and Media, Hanover, Germany.

Funding

Dalle Molle FoundationDeutsche Forschungsgemeinschaft 323965454Edith Maryon FoundationKurt Fries FoundationSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 100019E-170410
6 · The paper itself

Abstract

Although hobbies can improve quality of life (QoL), the role that music might play in healthy aging still needs to be established. The aim of the present study was to investigate the causal influence of piano practice on QoL in seniors. Furthermore, we aimed to identify brain regions of the reward circuit that are related to QoL and piano practice. The present randomized controlled trial included 156 older, healthy participants. All participants were randomly assigned to either piano practice or music listening groups and attended weekly 60-min lessons for 12 months. At 0, 6, 12, 18, and ∼48 months, QoL was assessed using the WHOQOL-BREF questionnaire. Gray matter volume was evaluated from T1-weighted MRI data acquired at the first four time points. Practicing piano positively impacted the psychological (log-odds 0.13, 90% credible interval [0.01, 0.26]), physical (0.22 [0.05, 0.39]), and environmental (0.18 [0.01, 0.35]) QoL. Social QoL did not change between groups. Furthermore, changes in QoL were positively associated with bilateral amygdala and left pallidal volume increases. In conclusion, offering piano lessons could be a worthwhile approach to promote healthy aging and improve seniors' QoL.

Indexed as

AgingHealthy AgingMusicQuality of LifeAgedBrainFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedSurveys and Questionnairesamygdalahealthy agingmagnetic resonance imagingmusicquality of liferandomized controlled trialwell‐being

Identifiers

PMID40571975
PMCPMC12412713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.