Evidence map›Paper›PMID 40571970›Full record

ArticleEuropean journal of haematology2025

European Expert Panel Consensus on Outpatient Administration of Teclistamab and Talquetamab in Patients With Multiple Myeloma: Feasibility, Key Considerations, and Future Directions.

Thomas Lund, Cyrus Khandanpour, Sébastien Anguille, Jens Kisro, Maria Theresa Krauth, Johan Lund, Inger Nijhof, Enrique M Ocio, Elena Zamagni, Matthieu Javelot and 3 more

Abstract readConsensus Statement
In one paragraph

Article in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thomas LundDepartment of Hematology, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0003-3509-3780
Cyrus KhandanpourUniversity Hospital Schleswig-Holstein and University Cancer Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
Sébastien AnguilleDivision of Hematology, Antwerp University Hospital, Edegem, Belgium.
Jens KisroLübecker Onkologische Schwerpunktpraxis, Lübeck, Germany.
Maria Theresa KrauthDepartment of Medicine I, Division Hematology and Hemostaseology, Medical University Vienna, Vienna, Austria.
Johan LundKarolinska Institute, Stockholm, Sweden.
Inger NijhofSt Antonius Hospital, Nieuwegein, the Netherlands.
Enrique M OcioDepartment of Hematology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain.
Elena ZamagniDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Matthieu JavelotJohnson & Johnson, Issy-les-Moulineaux, France.
Claire AlbrechtJohnson & Johnson, Issy-les-Moulineaux, France.
Cristina Entrala CerezoJohnson & Johnson, Madrid, Spain.
Aurore PerrotInstitut Universitaire du Cancer de Toulouse, Toulouse, France.

Funding

Johnson & Johnson Global Services LLC
6 · The paper itself

Abstract

objectivesTeclistamab and talquetamab treatments are typically initiated in a hospital due to the potential risk of cytokine release syndrome. However, emerging data support the potential for outpatient administration (i.e., administration without overnight hospital admission). An expert consensus survey and meeting were conducted among European specialists in multiple myeloma treatment to evaluate current and future outpatient administration with teclistamab and talquetamab in clinical practice.

methodsAll experts completed a 17-question survey, participated in an individual follow-up call, and attended an online consensus meeting in September 2024.

resultsThere was strong agreement that outpatient treatment with teclistamab and talquetamab is feasible, with implementation already seen in some centers. Factors identified as potential criteria to define patient eligibility include cognitive status, caregiver presence, and distance from the hospital. While outpatient administration is not yet widely adopted due to limited experience with bispecific antibodies, the expert panel expects up to 50% of patients receiving teclistamab and talquetamab could be treated in an outpatient setting within 3 years.

conclusionsSharing best practices, robust protocol development, and evidence from clinical trials and real-world experience will support the implementation of outpatient treatment with bispecific antibodies, which could relieve hospital resources and improve patients' treatment experience.

Indexed as

Ambulatory CareAntibodies, BispecificAntineoplastic Agents, ImmunologicalMultiple MyelomaEuropeHumansOutpatientsTreatment OutcomeAntibodies, BispecificAntineoplastic Agents, ImmunologicaltalquetamabantibodiesbispecificconsensusEuropehematologymultiple myelomaoutpatientstalquetamabteclistamab

Identifiers

PMID40571970
PMCPMC12402850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.