ArticleBMC veterinary research2025
Antitrypanosomal potential of Salvia officinalis terpenoids-rich fraction in Trypanosoma evansi-infected rat model.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Anti-trypanosomal, anti-inflammatory, and neuroprotective effects of Cichorium intybus sesquiterpene lactones in experimental Trypanosoma evansi infection.Scientific reports · 2026Article
- Linking Ghrelin Elevation to Reproductive Dysfunction: Insights from Feed-Restricted Male Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
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Authors and funding
8 authors.
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Abstract
background trypanosoma evansi(T. evansi) is a major protozoan disease that affects animals, including camels, and causes substantial economic detriments. The failure to control T. evansi infections is due to the unavailability of vaccines and the development of resistance to existing chemical drugs. In this study, we evaluated the effect of Salvia officinalis terpenoids-rich fraction on the degree of parasitemia and associated pathological alterations in rats experimentally infected with T. evansi.
methodEighty adult male rats were equally divided into 4 groups. The first group was a negative control. The second group was intraperitoneally infected with T. evansi at a dose of 1 × 10
resultThe infection with T. evansi resulted in normocytic normochromic anemia, leukocytosis, hypoglycemia, hypertriglyceridemia, an increase in very low-density lipoprotein (VLDL) cholesterol, and reductions in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterols. Additionally, the infection induced upregulation of the pro-inflammatory cytokines such as interleukin-1beta (IL-1β) and interleukin-6 (IL-6), and downregulation of the anti-inflammatory cytokines such as interleukin-10 (IL-10) and transforming growth factor beta (TGF-β). Besides histopathological changes in the brain and spleen, T. evansi markedly elevated brain oxidative stress and acetylcholinesterase (AChE) activity. The treatment with salvia fraction significantly decreased the degree of parasitemia and mitigated the T. evansi-induced pathological alterations.
conclusionThe terpenoids-rich fraction from Salvia officinalis exhibits antitrypanosomal activity and may serve as a promising candidate for developing novel trypanocidal agents.
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