Evidence map›Paper›PMID 40571935›Full record

ReviewMilitary Medical Research2025

γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.

Zhong-Peng Dai, Qiang Wen, Ping Wu, Yan-Ni Zhang, Cai-Lian Fang, Meng-Yuan Dai, Hong-Liang Zhou, Huan Wang, Hao Tang, Si-Qi Zhang and 4 more

Abstract readReview
In one paragraph

Review in Military Medical Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhong-Peng DaiAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Qiang WenAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Ping WuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Yan-Ni ZhangAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Cai-Lian FangRehabilitation Medicine Department, Lishui Central Hospital, Lishui, 323000, Zhejiang, China.
Meng-Yuan DaiRehabilitation Medicine Department, Lishui Central Hospital, Lishui, 323000, Zhejiang, China.
Hong-Liang ZhouDepartment of Psychology, the Affiliated Hospital of Jiangnan University, Wuxi, 214062, Jiangsu, China.
Huan WangSchool of Computer Science and Artificial Intelligence, Changzhou University, Changzhou, 213159, Jiangsu, China.
Hao TangDepartment of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Si-Qi ZhangInstitutes Sciences Cognitives Marc Jeannerod, CNRS UMR 5229, Lyon, France.
Xiao-Kun LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. xiaokunli@wmu.edu.cn.
Jian-Song JiZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China. jijiansong@zju.edu.cn.
Liu-Xi ChuAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China. clx0605@wmu.edu.cn.
Zhou-Guang WangThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. wzhouguang@gmail.com.ORCID 0000-0001-9903-0362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ neuromodulation has emerged as a promising strategy for addressing neurological and psychiatric disorders, particularly in regulating executive and cognitive functions. This review explores the latest neuromodulation techniques, focusing on the critical role of γ oscillations in various brain disorders. Direct γ neuromodulation induces γ-frequency oscillations to synchronize disrupted brain networks, while indirect methods influence γ oscillations by modulating cortical excitability. We investigate how monitoring dynamic features of γ oscillations allows for detailed evaluations of neuromodulation effectiveness. By targeting γ oscillatory patterns and restoring healthy cross-frequency coupling, interventions may alleviate cognitive and behavioral symptoms linked to disrupted communication. This review examines clinical applications of γ neuromodulations, including enhancing cognitive function through 40 Hz multisensory stimulation in Alzheimer's disease, improving motor function in Parkinson's disease, controlling seizures in epilepsy, and modulating emotional dysfunctions in depression. Additionally, these neuromodulation strategies aim to regulate excitatory-inhibitory imbalances and restore γ synchrony across neurological and psychiatric disorders. The review highlights the potential of γ oscillations as biomarkers to boost restorative results in clinical applications of neuromodulation. Future studies might focus on integrating multimodal personalized protocols, artificial intelligence (AI) driven frameworks for neural decoding, and global multicenter collaborations to standardize and scale precision treatments across diverse disorders.

Indexed as

BiomarkersGamma RhythmMental DisordersNervous System DiseasesHumansBiomarkersCross frequency couplingDeep brain stimulation (DBS)Neurological disordersNeuromodulationPsychiatric disordersTranscranial magnetic stimulation (TMS)γ oscillations

Identifiers

PMID40571935
PMCPMC12203730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.