Observational studyBMC pediatrics2025
Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children.
Observational study in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sonographic optic nerve sheath diameter measurement for detecting intracranial hypertension in a suspected population: a systematic review and meta-analysis of diagnostic thresholds and influencing factors.Journal of neurology · 2026Pooled it
- Orbital Doppler Ultrasonography and Optic Nerve Sheath Diameter in Pediatric Brain Death Evaluation.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRaised intracranial pressure (ICP) is a typical neurological problem in critically ill children, which is associated with poor clinical outcomes or even death. The purpose of the study was to evaluate the efficacy of optic nerve sheath diameter (ONSD) as a point-of-care testing in the pediatric intensive care units for early diagnosis of raised intracranial pressure and as a follow up tool for treatment response.
methodA prospective observational study was conducted in the pediatric intensive care unit of a tertiary care children's hospital. Consecutive children aged one month to twelve years with Glasgow Coma Scale less than or equal to 8 were included. Brain CT was performed just before or within few hours of admission to identify raised ICP. Two trained examiners in the same work place, who were blinded to the clinical details of the patients, performed the ONSD sonography concurrently. The ONSD was measured in the left and right eyes on admission, after 1 h, after 12 h, and after 24 h.
resultsForty-two patients were categorized into 29 children with raised ICP and 13 children with non-raised ICP. The ONSD was significantly higher in the raised ICP group at all times in both eyes. It showed a significant decrease over time in both groups. A cutoff value of ≥ 4.3 mm was found to be an acceptable discriminator of ICP with Area Under the ROC curve (AUC) = 0.788 (95% CI 0.740- 0.830) (p < 0.0001), sensitivity of 59.91% (95% CI: 53.30-66.27) and specificity of 83.65% (95% CI: 75.12-90.18).
conclusionsIn critically ill children with non-traumatic causes of raised ICP, point of care ultrasound of ONSD shows a good diagnostic test accuracy for early diagnosis of raised ICP as well as follow up tool of treatment response if used serially. In addition, it is very good at correctly identifying individuals who do not have raised ICP to avoid unnecessary interventions.
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