ArticleBMC microbiology2025
Epothilone B from Aspergillus fumigatus with a strong antiproliferative and anti-tubulin polymerizing activities; apoptosis, and cell cycle analyses.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Endophytic Aspergillus glaucus as a novel epothilone B producer: Antiproliferative activity and in silico analysis.Applied microbiology and biotechnology · 2026Article
- Bioprocessing of monomethyl ether from Alternaria alternata, a multi-target antiproliferative compound as emphasized by in silico analysis.Scientific reports · 2026Article
- Cladosporium cladosporioides, endophyte of Strelitzia nicolai, as a new producer of Alternariol monomethyl ether with a potential cytotoxic activity.Scientific reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epothilones were designated as one of the most recognized chemotherapeutic agents towards the drug-resistant tumors, for their higher potency to bind and stabilize the β-tubulin arrays, stopping the cell cycle. Epothilones were chemically resolved from Aspergillus fumigatus # MN744705.1, that being more affordable source than Sorangium cellulosum, for its rapid growth and unique biological behaviour. So, the aim of this work was to emphasize the chemical identity and efficacy of Aspergillus fumigatus Epothilone. The Epothilone structure of A. fumigatus was determined by HPLC, FT-IR, LC-MS analyses, with 507.7 m/z, compared to the authentic one of S. cellulosum. Aspergillus fumigatus epothilone B had the highest activity against HepG-2 (IC
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