ArticleCell biochemistry and biophysics2025
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Digitoxin inhibits the growth of HSC-3 cells by inducing G2/M cell cycle arrest and apoptosis.Translational cancer research · 2026Article
- Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.Hereditas · 2026Article
- Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Oxidative stress results in the apoptosis of ovarian granulosa cells (GCs) and premature ovarian failure (POF). Ginsenoside Rg1 possesses natural antioxidant and anti-apoptotic properties. However, the underlying mechanisms by which it regulates mitochondrial function in ovarian GCs remain unclear. To investigate the potential mechanism of ginsenoside Rg1 (Rg1) in mitigating oxidative stress, autophagy and apoptosis in POF. This study employed network pharmacology and in vitro experiments to identify the key targets and pathways associated with the therapeutic effects of Rg1 in the treatment of POF. An oxidative stress model was established using H₂O₂-treated KGN cells to validate the network pharmacology predictions in vitro. In the Rg1-treated group, cell viability was significantly improved, while the rate of apoptosis was reduced. Furthermore, Rg1 suppressed the production of reactive oxygen species and malondialdehyde, and increased the levels of glutathione and adenosine triphosphate. Additionally, Rg1 downregulated pro-apoptotic and mitophagy-related markers (Bax, Caspase-3, Parkin, PINK1) and upregulated Bcl-2, p-PI3K, p-AKT, and p-mTOR, suggesting involvement of the PI3K/AKT/mTOR signaling pathway. These findings suggest that Rg1 protects against H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.