ArticleBiological trace element research2026
Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Protective effects of caffeine on aluminum-induced ovarian toxicity in a mouse model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Juglone Protects Against CLP-Induced Sepsis by Regulating Apoptosis, Pyroptosis, and Oxidative Stress Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Silymarin Modulates 3-Nitropropionic Acid-Induced Oxidative Neurotoxicity and Apoptosis Through the Inhibition of TRPV1 Channel in Mouse Brain and Hippocampal Neurons.Journal of biochemical and molecular toxicology · 2026Article
- Exploring the renoprotective effects of umbelliferone in rats subjected to ischemia/reperfusion injury.Iranian journal of basic medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In our study, the potential protective effects of boric acid (BA) against ovarian damage induced by 3-nitropropionic acid (3-NPA) were investigated. In an experiment conducted on female Wistar rats, the animals were divided into groups receiving control, 3-NPA, 3-NPA + BA, and BA only. 3-NPA triggers oxidative stress in the body by inducing excessive production of reactive oxygen species (ROS), leading to cellular damage and apoptosis. Experimental results showed that oxidative stress markers (MDA, GSH, and GSH-Px) increased in the group treated with 3-NPA, along with elevated inflammatory and apoptotic indicators (TNF-α, IL-6, NF-κB, caspase 3, and 9). Moreover, significant histopathological findings such as degeneration, necrosis, and oocyte loss in follicles were observed. Boric acid application significantly reduced these adverse effects, enhancing antioxidant defense and providing protective effects on ovarian tissue. In conclusion, it was observed that BA's antioxidant and anti-apoptotic properties exhibited protective potential against 3-NPA-related ovarian damage, with a positive impact on reproductive health. The study suggests that BA might be used as a supportive agent in diseases of the female reproductive system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.