Evidence map›Paper›PMID 40571872›Full record

ArticlePharmaceutical research2025

The Impact of Drug Properties and Severity of Obesity on Renal Drug Clearance Through Glomerular Filtration and Active Tubular Secretion: A Systematic Analysis Using PBPK Modeling.

Tan Zhang, Elisa A M Calvier, Elke H J Krekels, Catherijne A J Knibbe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tan ZhangDivision of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Elisa A M CalvierPharmacokinetics-Dynamics and Metabolism, Translational Medicine and Early Development, Sanofi R&D, Montpellier, France.
Elke H J Krekels *Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Catherijne A J Knibbe *Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. c.knibbe@antoniusziekenhuis.nl.ORCID http://orcid.org/0000-0001-9893-4415

Funding

China Scholarship Council 201906010328
6 · The paper itself

Abstract

objectiveThe influence of obesity on renal drug clearance (CLr) remains difficult to predict. This study quantifies obesity-related alterations in CLr for drugs eliminated via glomerular filtration (GF/CL

methodsA physiologically-based pharmacokinetic (PBPK) approach was used to simulate CL

resultsCLr through GF and ATS increased with BMI, albeit to different extents, depending on drug properties. When BMI was below 30 kg/m

conclusionIn individuals with a BMI above 30 kg/m

Indexed as

Glomerular Filtration RateKidney TubulesModels, BiologicalObesityRenal EliminationAdultBody Mass IndexFemaleHumansMaleMetabolic Clearance RateMiddle AgedPharmaceutical PreparationsPharmacokineticsPharmaceutical Preparationsallometric scalingclearance scalingobesityPBPK modelingrenal transporter activity

Identifiers

PMID40571872
PMCPMC12304071

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.