ArticleIntensive care medicine experimental2025
Digital twins suggest a mechanistic basis for differing responses to increased flow rates during high-flow nasal cannula therapy.
Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Digital twins in pulmonary medicine: a scoping review of applications, benefits, and challenges.BMC pulmonary medicine · 2026Article
- Computational tools for personalizing treatment of acute respiratory failure, from machine learning to digital twins: a narrative review.Critical care (London, England) · 2026Review
- Bi-level HFNC: A promising approach for optimizing and individualize respiratory support?Intensive care medicine · 2026Article
- Knowledge gaps in extracorporeal blood purification: what would be required for its successful application in septic shock?Intensive care medicine experimental · 2025Review
- Digital twin applications in adult critical care: A scoping review of current development and implementation trends.Digital healthReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundInconsistent responses to increased flow rates have been observed in patients with acute hypoxemic respiratory failure (AHRF) treated with high-flow nasal cannula (HFNC) therapy, with a significant minority in two recent studies exhibiting increased respiratory effort at higher flow rates. Digital twins of patients receiving HFNC could help understand the physiological basis for differing responses.
methodsPatient data were collated from previous studies in AHRF patients who were continuously monitored with electrical impedance tomography and oesophageal manometry and received HFNC at flow rates of 30, 40 or 45 L/min. Patients, based on their responses to an increase in flow rate to 60 L/min, were categorised into two groups: five responders with reduced oesophageal pressure swings ΔP
resultsThe digital twins accurately replicated patient-specific responses at all flow rates. Responder digital twins showed a mean 20 mL/cmH
conclusionsFailure to reduce spontaneous respiratory efforts in response to increased HFNC flow rates could be due to a deterioration in lung mechanics, with an attendant risk of P-SILI.
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