Evidence map›Paper›PMID 40571795›Full record

ArticleSurgical endoscopy2025

Surgical outcomes of conventional versus indocyanine green fluorescence-guided laparoscopic cholecystectomy in acute cholecystitis: a propensity score-matched analysis.

Camilo Ramírez-Giraldo, Chiara Bimbo, Nicolò Fabbri, Mario Bertasi, Carlo Feo, Antonio Pesce

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camilo Ramírez-GiraldoDepartment of Surgery, Hospital Universitario Mayor - Méderi, Bogotá, Colombia.
Chiara BimboUniversity of Ferrara, Ferrara, Italy.
Nicolò FabbriDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, Via Valle Oppio, 2, 44023, Lagosanto, FE, Italy.
Mario BertasiDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, Via Valle Oppio, 2, 44023, Lagosanto, FE, Italy.
Carlo FeoDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, Via Valle Oppio, 2, 44023, Lagosanto, FE, Italy.
Antonio PesceDepartment of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, Via Valle Oppio, 2, 44023, Lagosanto, FE, Italy. nino.fish@hotmail.it.ORCID http://orcid.org/0000-0002-7560-551X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEarly laparoscopic cholecystectomy remains the gold standard for managing acute cholecystitis. Intraoperative fluorescent cholangiography using indocyanine green (ICG) has emerged as a promising technique to enhance surgical safety by improving visualization of biliary anatomy, reducing bile duct injuries, and decreasing the incidence of failed critical view of safety (CVS), thereby minimizing the need for bailout procedures. This study aimed to compare surgical outcomes, particularly the need for bailout procedures, between conventional (white-light) and ICG fluorescence-guided laparoscopic cholecystectomy in patients with acute cholecystitis.

methodsA prospective cohort of patients undergoing ICG fluorescence-guided laparoscopic cholecystectomy (n = 101, January 2023 - December 2024) was compared with a retrospective control group treated with conventional laparoscopic cholecystectomy (n = 84, January 2021 - December 2022) at the same institution. Propensity score matching (1:1 ratio) was employed to minimize selection bias and confounding variables.

resultsPatients in the fluorescence-guided group had a significantly lower rate of bailout procedures compared to the conventional group. No statistically significant differences were observed between the groups in secondary outcomes, including operative time, length of hospital stay, reintervention rates, and major complications (Clavien-Dindo grade ≥ III). Binary logistic regression confirmed a significant reduction in the risk of bailout procedures with fluorescence guidance (OR = 0.05; 95% CI: 0.00-0.33), while no other covariates reached statistical significance.

conclusionBased on our findings, the use of ICG fluorescence was associated with a reduced need for bailout procedures. Further multicenter prospective studies are necessary to validate these results and assess long-term outcomes.

Indexed as

Cholecystectomy, LaparoscopicCholecystitis, AcuteIndocyanine GreenSurgery, Computer-AssistedAdultAgedCholangiographyColoring AgentsFemaleFluorescenceHumansLength of StayMaleMiddle AgedOperative TimeOptical ImagingColoring AgentsIndocyanine GreenAcute cholecystitisBail-out proceduresCritical view of safetyFluorescenceIndocyanine greenLaparoscopic cholecystectomy

Identifiers

PMID40571795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.