Evidence map›Paper›PMID 40571792›Full record

ArticleSurgical endoscopy2025

Medication cost for treatment of metabolic dysregulation decreases following adolescent bariatric surgery.

Abigail J Alexander, Hannah Wilcox, Joshua John Horns, Marshall W Wallace, Rupam Das, Katie W Russell, Anna R Ibele

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Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Abigail J AlexanderDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA. Abby.Alexander@hsc.utah.edu.ORCID http://orcid.org/0009-0007-6244-6656
Hannah WilcoxDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA.
Joshua John HornsDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA.
Marshall W WallaceDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA.
Rupam DasDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA.
Katie W RussellDivision of Pediatric Surgery, Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.
Anna R IbeleDivision of General Surgery, University of Utah, 50 Medical Drive N, Salt Lake City, Utah, 84132, USA.

Funding

NIH HHS 1S10OD021644-011A1
6 · The paper itself

Abstract

backgroundThe burden of obesity-related metabolic dysfunction in adolescents is skyrocketing; the purpose of this study is to understand the impact of adolescent bariatric surgery on the utilization and cost of medications for treatment of metabolic dysregulation.

methodsUsing the MarketScan database of commercial health insurance claims from 2011-2019, bariatric surgery patients ages 14-18 (n = 992) were assessed for patterns of medication utilization pre-surgery (beginning of MarketScan enrollment to 6 months before surgery) and post-surgery (> 12 months after surgery). We examined the cost and rate of prescription fills for diabetes, cardiovascular, and dyslipidemia medications. We calculated standardized utilization rates and ran generalized estimating equations for utilization and cost of each medication with Poisson distribution to test for differences at the various time intervals. We also compared utilization and cost for the surgical patients two three control groups, stratified based on body mass index.

resultsUtilization of diabetes and dyslipidemia medications showed a significant decrease in the incidence rate ratio (95% confidence interval) for the post-surgery period relative to the pre-surgery period (0.428 (0.223-0.82) p = 0.01; 0.194 (0.056-0.667) p < 0.01). The total annual cost for the entire cohort of bariatric surgery patients (95% confidence interval) also decreased after surgery with dyslipidemia medications decreasing by $8,666.11 ($1011.84-$16,308.48), cardiovascular medications decreasing by $33,890.68 ($14,403.84-$53,389.44) and diabetes medications decreasing by $45,949.44 ($3,083.14-$94,993.92).

conclusionFollowing adolescent bariatric surgery, there is a decrease in utilization of diabetes and dyslipidemia medications. There was decreased cost for diabetes, dyslipidemia, and cardiovascular medications. These results suggest that performing bariatric surgery during late adolescence is associated with overall improvements in metabolic health.

Indexed as

Bariatric SurgeryDrug CostsDyslipidemiasPediatric ObesityAdolescentFemaleHumansHypoglycemic AgentsMaleRetrospective StudiesHypoglycemic AgentsAdolescent bariatric surgeryMedication costsMetabolic dysregulation

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.