ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Refractive factors affecting the persistence of anisometropia in preschool-aged children.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Age-continuous centile curves reveal upper-tail divergence of anisometropia in 389 056 schoolchildren: implications for risk stratification in myopia control.BMJ open ophthalmology · 2026Article
- The Changing Natural History of Anisometropia: A Scoping Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Refractive and visual changes in the fellow eye after unilateral refractive surgery in patients with anisometropia.Frontiers in medicine · 2026Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposePediatric vision screening programs can detect children with amblyopic anisometropia. We aim to determine which refractive factors may be associated with the persistence of anisometropia in this population.
methodsA cohort analysis included all children aged one to six years, evaluated for refractive status between 2012 and 2022 at the Maccabi Healthcare Services. Refractive data were collected at presentation and at a subsequent follow-up visit. Logistic regression models were used to analyze relationships between baseline refractive error and anisometropia at follow-up.
resultsOf 35,854 children evaluated, 6.6% (n = 2,358) had anisometropia at presentation. Those with a baseline anisometropia of ≥ 3.0 diopters exhibited a higher prevalence of anisometropia at the last follow-up compared to those with a baseline anisometropia of a lesser magnitude; when the more ametropic eye was hyperopic (73.5% vs. 41.4%, respectively, p < 0.001) or myopic (62.5% vs. 41.8%, respectively, p = 0.009). Adjusted odds ratios for anisometropia at follow-up increased with greater levels of baseline anisometropia with the more ametropic eye being hyperopic (OR = 3.75, 95% CI 2.57 - 5.48) or myopic (OR = 2.19, 95% CI 1.11 - 4.33). A higher degree of hyperopia, myopia and astigmatism at baseline demonstrated similar patterns.
conclusionIn anisometropic preschool-aged children, higher degrees of baseline anisometropia, hyperopia, myopia and astigmatism, are associated with a higher prevalence of future anisometropia. The likelihood for later anisometropia increases with greater levels of baseline anisometropia, hyperopia, myopia and astigmatism. KEY MESSAGES: What is known Higher refractive errors, lifestyle factors and educational levels have been considered as risk factors for anisometropia. Severe anisometropia at young age is more prone to persist. What is new In this cohort of 2,358 anisometropic preschool-aged children, the likelihood for anisometropia at the last follow-up has increased considerably when, at baseline, the more ametropic eye was hyperopic. It has also increased with astigmatic hyperopia, which possibly underscores the combined effect of astigmatism and hyperopia on anisometropia persistence. These findings were independent of socio-economic status, body mass index, and country of birth.
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