Evidence map›Paper›PMID 40571754›Full record

ArticleNature medicine2025

Immune impacts of fire smoke exposure.

Mary M Johnson, Abhinav Kaushik, Olivia A Kline, Eric M Smith, Xiaoying Zhou, Yagiz Pat, Laura Buergi, Juan Aguilera, Shifaa Alkotob, Elisabeth M Simonin and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Observational
  4. Update on environmental determinants of allergic diseases.The Journal of allergy and clinical immunology · 2026
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mary M Johnson *Deparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abhinav Kaushik *Deparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Olivia A KlineDeparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Eric M SmithDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Xiaoying ZhouDeparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yagiz PatSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Laura BuergiSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Juan AguileraCenter for Community Health Impact, The University of Texas Health Science Center at Houston School of Public Health, El Paso, TX, USA.ORCID http://orcid.org/0000-0002-6451-0662
Shifaa AlkotobDivision of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Elisabeth M SimoninDeparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9195-5061
Alberto FavaroFaculty Science Limited, London, UK.
Miguel CoutoFaculty Science Limited, London, UK.
Oscar BennettFaculty Science Limited, London, UK.ORCID http://orcid.org/0000-0003-4546-1807
R Sharon ChinthrajahSean N. Parker Center for Allergy & Asthma Research, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2467-4256
Ella ParsonsSean N. Parker Center for Allergy & Asthma Research, Stanford University, Palo Alto, CA, USA.
Mohamed ShamjiImmunomodulation and Tolerance Group, Allergy and Clinical Immunology, Imperial College London, London, UK.
Marshall BurkeDoerr School of Sustainability, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-4288-5858
Melissa BondyDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Palo Alto, CA, USA.
Mubeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Kari C NadeauDeparment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. knadeau@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-2146-2955

Funding

Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
Scientific Human Biomarker Exposure Monitoring Core (HEMC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) StudyP01HL152953 · NHLBI · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2021 to 2025
$9.8M
Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution ExposureR01ES032253 · NIEHS · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2020 to 2024
$2.2M
NHLBI NIH HHS P01 HL152953NIAID NIH HHS U19 AI167903NIEHS NIH HHS R01 ES032253U.S. Department of Health & Human Services | National Institutes of Health (NIH) P01HL152953U.S. Department of Health & Human Services | National Institutes of Health (NIH) U19AI167903
6 · The paper itself

Abstract

Exposure to fire smoke has become a global health concern and is associated with increased morbidity and mortality. There is a lack of understanding of the specific immune mechanisms involved in smoke exposure, with preventive and targeted interventions needed. After exposure to fire smoke, which includes PM

Indexed as

FiresSmokeAdultBiomarkersCase-Control StudiesDNA MethylationEnvironmental ExposureFemaleHumansMaleMiddle AgedBiomarkersSmoke

Identifiers

PMID40571754
PMCPMC12696577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.