Evidence map›Paper›PMID 40571730›Full record

ArticleNature genetics2025

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression.

Tao Zhou, Yanhong Wu, Shuai Li, Xinyao Qiu, Erdong Liu, Zhihua Xie, Xuebing Shi, Yani Zhang, Guosheng Ma, Wenbo Guo and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Hypoxia-driven remodeling of SELENOPNature communications · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tao Zhou *The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-9782-7324
Yanhong Wu *MOE Key Laboratory of Bioinformatics, BNRIST Bioinformatics Division, Department of Automation, Tsinghua University, Beijing, China.
Shuai Li *Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Xinyao Qiu *The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Erdong Liu *Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Zhihua Xie *The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Xuebing ShiThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Yani ZhangInstitute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Guosheng MaThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Wenbo GuoMOE Key Laboratory of Bioinformatics, BNRIST Bioinformatics Division, Department of Automation, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-7973-6795
Xiang WangDepartment II of Biliary Tract, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Kaiting WangInstitute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Xiaomeng YaoDepartment of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Ji HuThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Siyun ShenThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Shuai YangFudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaoqing JiangDepartment I of Biliary Tract, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China. jxq1225@vip.sina.cn.ORCID http://orcid.org/0009-0005-0021-9285
Jing FuThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China. fujing@smmu.edu.cn.ORCID http://orcid.org/0009-0002-6769-525X
Hongyang WangThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China. hywangk@vip.sina.com.ORCID http://orcid.org/0000-0002-4709-3334
Jin GuMOE Key Laboratory of Bioinformatics, BNRIST Bioinformatics Division, Department of Automation, Tsinghua University, Beijing, China. jgu@tsinghua.edu.cn.ORCID http://orcid.org/0000-0003-3968-8036
Lei ChenThe International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China. chenlei@smmu.edu.cn.ORCID http://orcid.org/0000-0002-9380-9559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallbladder carcinoma (GBC) is the most aggressive biliary tract cancer and is associated with a high mortality rate. Treatment of GBC faces therapeutic challenges owing to the elusive nature of in situ drivers within the local tumor microenvironment that drive its progression. Here, we created a single-cell atlas of 1,117,245 cells and a mutational landscape from 102 patients, which unveiled spatial-temporal characterizations of cellular constitutions, spatial interplays and molecular functions, and generalized five local ecosystems stratifying clinical outcomes. An integrated epithelial program, AI-EPI, combined with spatial transcriptome analysis, revealed the concurrent localization of a highly malignant tumor subtype (GM16) and AREG

Indexed as

Gallbladder NeoplasmsTumor MicroenvironmentAnimalsCell Line, TumorChemokine CXCL5Disease ProgressionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiceMultiomicsMutationSignal TransductionSingle-Cell AnalysisChemokine CXCL5

Identifiers

PMID40571730

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.