Evidence map›Paper›PMID 40571659›Full record

ReviewJournal of Zhejiang University. Science. B2025

New characteristics of cancer immunotherapy: trends in viral tumor immunotherapy with influenza virus-based approaches.

Shiyao Hu, Yiqi Cai, Yong Shen, Yingkuan Shao, Yushen DU, Yiding Chen

Abstract readReview
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiyao HuDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yiqi CaiCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Yong ShenDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yingkuan ShaoDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yushen DUCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. lilyduyushen@zju.edu.cn.
Yiding ChenDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. ydchen@zju.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities 226-2024-00062the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang 2022R01002the National Natural Science Foundation of China 82272300 and 82102893
6 · The paper itself

Abstract

Immunomodulatory cancer therapy is witnessing the rise of viral immunotherapy. The oncolytic influenza A virus, although promising in preclinical investigations, remains to be implemented in clinical practice. Recent progress in genetic engineering, coupled with experiential insights, offers opportunities to enhance the therapeutic efficacy of the influenza A virus. This review explores the use of the influenza virus, its attenuated forms, and associated vaccines in cancer immunotherapy, highlighting their respective advantages and challenges. We further elucidate methods for engineering influenza viruses and innovative approaches to augment them with cytokines or immune checkpoint inhibitors, aiming to maximize their clinical impact. Our goal is to provide insights essential for refining influenza A virus-based viral tumor immunotherapies.

Indexed as

ImmunotherapyInfluenza A virusNeoplasmsOncolytic VirotherapyAnimalsCancer VaccinesGenetic EngineeringHumansImmune Checkpoint InhibitorsOncolytic VirusesCancer VaccinesImmune Checkpoint InhibitorsAntitumorInfluenza A virusOncolytic virusReverse genetic technologyVaccineViral immunotherapy

Identifiers

PMID40571659
PMCPMC12219492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.