Evidence map›Paper›PMID 40571625›Full record

ArticleNeuropsychopharmacology reports2025

Clinical Characteristics of Patients With Enlarged Ventricles and Cognitive Impairment (EVCI): Case Series.

Yuka Yasuda, Satsuki Ito, Junya Matsumoto, Toshiaki Onitsuka, Hidenaga Yamamori, Michiko Fujimoto, Naomi Hasegawa, Manabu Ikeda, Ryota Hashimoto

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yuka YasudaLife Grow Brilliant Mental Clinic, Medical Corporation Foster, Osaka, Japan.ORCID https://orcid.org/0000-0002-2746-1590
Satsuki ItoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Junya MatsumotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4228-3208
Toshiaki OnitsukaNHO Sakakibara National Hospital, Tsu, Mie, Japan.
Hidenaga YamamoriDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2100-1881
Michiko FujimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Naomi HasegawaDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Manabu IkedaDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5941-4238

Funding

Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP 3-1Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP 4-6Japan Agency for Medical Research and Development JP21dk0307103Japan Agency for Medical Research and Development JP21uk1024002Japan Agency for Medical Research and Development JP21wm0425012Japan Society for the Promotion of Science JP20H03611Japan Society for the Promotion of Science JP23H00395Japan Society for the Promotion of Science JP23K07001
6 · The paper itself

Abstract

backgroundSince research on the pathophysiology of psychiatric disorders diagnosed by symptoms has not succeeded, a data-driven analysis incorporating biological and cross-disease perspectives has been proposed. We have reported a new subgroup of psychiatric disorders by a data-driven analysis of subcortical volumes of brain MRI in 5602 subjects, including patients with psychiatric disorders and controls. This subgroup of patients is characterized by enlarged ventricle and cognitive impairment (EVCI) with a high proportion of schizophrenia, electroencephalography abnormalities, and rare pathological copy number variations. CASE PRESENTATION: Of the nine patients with EVCI, eight patients had schizophrenia, and one patient had autism spectrum disorder. Early onset of age was observed in eight patients with schizophrenia. Treatment responses were poor in seven patients with schizophrenia, and two of three treatment-resistant schizophrenia patients responded to clozapine. Four patients showed ischemic changes in cerebral white matter. In electroencephalography, abnormal findings were observed in five patients, borderline findings in two patients, and normal findings in two patients. Rare pathogenic copy number variations were found in three patients (22q11.21 deletion, 7q11.23 duplication, and 7q36.2 deletion).

conclusionsThe results of this case series showed additional clinical features of treatment response and ischemic changes in cerebral white matter, which could be a clue to the treatment and diagnosis of EVCI. This case series might help elucidate the pathophysiology of EVCI.

Indexed as

Autism Spectrum DisorderCerebral VentriclesCognitive DysfunctionSchizophreniaAdultDNA Copy Number VariationsElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adultcognitive impairmentelectroencephalography abnormalitiesenlarged ventriclesischemic changes in cerebral white mattertreatment‐resistant schizophrenia

Identifiers

PMID40571625
PMCPMC12202129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.