Evidence map›Paper›PMID 40571620›Full record

ReviewInternal medicine (Tokyo, Japan)2026

5-Fluorouracil-Related Lactic Acidosis in a Patient with Colon Cancer.

Yosuke Osawa, Manami Kazaoka, Takayuki Akita, Daiki Nemoto, Takaaki Ohtake

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yosuke OsawaDepartment of Gastroenterology, International University of Health and Welfare Hospital, Japan.
Manami KazaokaDivision of Pharmacology, International University of Health and Welfare Hospital, Japan.
Takayuki AkitaDepartment of Gastroenterology, International University of Health and Welfare Hospital, Japan.
Daiki NemotoDepartment of Gastroenterology, International University of Health and Welfare Hospital, Japan.
Takaaki OhtakeDepartment of Gastroenterology, International University of Health and Welfare Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon cancer is one of the most common cancers and 5-fluorouracil (5-FU) has long been used as a primary chemotherapeutic agent. Lactic acidosis following systemic 5-FU exposure is rare. We report the case of a 36-year-old woman who developed lactic acidosis following mFOLFOX6 and FOLFIRI therapy for colon cancer with metastases to the liver, lungs, and brain. Two days after receiving 5-FU, the patient exhibited unconsciousness, convulsions, and a lactate level of 10 mmol/L. Her altered consciousness and convulsions improved with sodium bicarbonate treatment. In addition, we reviewed the relevant literature on lactic acidosis following 5-FU treatment in patients with colon cancer.

Indexed as

Acidosis, LacticAntimetabolites, AntineoplasticColonic NeoplasmsFluorouracilAdultAntineoplastic Combined Chemotherapy ProtocolsCamptothecinFemaleHumansLeucovorinOrganoplatinum CompoundsAntimetabolites, AntineoplasticCamptothecinFluorouracilLeucovorinOrganoplatinum Compounds5-fluorouracilcolon cancerlactic acidosis

Identifiers

PMID40571620
PMCPMC12900583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.