Evidence map›Paper›PMID 40571613›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Continuously High Titers of Multiple Islet-associated Autoantibodies in an Individual with an Elderly Onset of Type 1 Diabetes Mellitus and Basedow's Disease: A Case Report with a Review of Literature.

Mana Ohnishi, Takatoshi Anno, Kaio Takahashi, Seizo Okauchi, Kazutoshi Murakami, Kohei Kaku, Hideaki Kaneto, Shinji Kamei

Abstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mana OhnishiDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.
Takatoshi AnnoDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.
Kaio TakahashiDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.
Seizo OkauchiDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.
Kazutoshi MurakamiDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.
Kohei KakuDepartment of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Japan.
Hideaki KanetoDepartment of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Japan.
Shinji KameiDepartment of Diabetic Medicine, Kurashiki Central Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cases of the elderly onset of type 1 diabetes mellitus (T1DM), multiple islet-associated autoantibodies tend to be less prevalent with increasing age at the diagnosis. In addition, the titers of various islet-associated autoantibodies decrease and often disappear within several years, according to the increasing duration of diabetes. A few reports have described the titers of various islet-associated autoantibodies in cases of the elderly onset of T1DM and Basedow's disease. We herein report an elderly patient with a T1DM onset under poorly controlled Basedow's disease, wherein the titers of various islet-associated autoantibodies remained very high for over five years.

Indexed as

AutoantibodiesDiabetes Mellitus, Type 1Islets of LangerhansAgedAge of OnsetFemaleHumansMaleAutoantibodiesautoimmune antibodyBasedow's diseaseelderly patienthigh-titertype 1 diabetes mellitus

Identifiers

PMID40571613
PMCPMC12900588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.