Evidence map›Paper›PMID 40571314›Full record

ArticleCancer genomics & proteomics2025

C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness.

Yusuke Otani, Masaki Maekawa, Atsushi Tanaka, Tirso Peña, Vanessa D Chin, Anna Rogachevskaya, Shinichi Toyooka, Michael H Roehrl, Atsushi Fujimura

Abstract read
In one paragraph

Article in Cancer genomics & proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  3. Cancer genomics & proteomics
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yusuke Otani *Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Masaki Maekawa *Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Atsushi Tanaka *Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Tirso PeñaDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Vanessa D ChinUMass Chan Medical School, UMass Memorial Medical Center, Worcester, MA, U.S.A.
Anna RogachevskayaDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Shinichi ToyookaDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Michael H RoehrlDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.
Atsushi FujimuraDepartment of Molecular Physiology, Kagawa University Faculty of Medicine, Graduate School of Medicine, Kagawa, Japan; fujimura.atsushi@kagawa-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimRecent advancements in omics analysis have significantly enhanced our understanding of the molecular pathology of malignant melanoma, leading to the development of novel therapeutic strategies that target specific vulnerabilities within the disease. Despite these improvements, the factors contributing to the poor prognosis of patients with malignant melanoma remain incompletely understood. The aim of this study was to investigate the role of MATERIALS AND

methodsWe performed comprehensive transcriptome data analysis and subsequent functional validation of the human Skin Cutaneous Melanoma project from The Cancer Genome Atlas (TCGA).

resultsElevated expression levels of

conclusionThis study is the first to identify

Indexed as

Biomarkers, TumorMelanomaNeoplastic Stem CellsSkin NeoplasmsCutaneous Malignant MelanomaDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMalePrognosisBiomarkers, TumorC1orf50cancer stem cellsmelanomaYAP/TAZ

Identifiers

PMID40571314
PMCPMC12216575

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.