Evidence map›Paper›PMID 40571161›Full record

ArticleTumour virus research2025

Human cytomegalovirus UL82 promotes colorectal cancer cell proliferation through inhibiting the ubiquitination of OGDH via ANGPT2.

Lanni Wang, Ruini Li, Haitao Ren, Chaoyi Jiang, Ye Shi, Bing Wang, Wenyu Jin, Jiaxue Wang, Linhua Lan, Feng Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tumour virus research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lanni WangDepartment of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Ruini LiSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Haitao RenDepartment of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Chaoyi JiangDepartment of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Ye ShiSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Bing WangSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Wenyu JinSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Jiaxue WangSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Linhua LanKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Feng XuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Guangxin XiangSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China.
Xiaoqun ZhengDepartment of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China; The Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, 325035, China. Electronic address: jszhengxq@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) infection and its association with tumorigenesis and tumor progression have garnered increasing attention. Previous research results have indicated that the detection rate of HCMV UL82 is higher in colorectal cancer (CRC) tissues and is correlated with poor prognosis in patients, yet the underlying mechanisms remain unclear. In this study, a cell model transfected with UL82 was established. Through in vitro and in vivo experiments, it was found that UL82 promoted the proliferation of CRC cells. Transcriptomic and metabolomic analyses revealed that UL82 could influence CRC glucose metabolism and cell proliferation by upregulating the key TCA cycle enzyme OGDH. Additionally, UL82 also affected CRC cell proliferation by upregulating the expression of ANGPT2, and silencing ANGPT2 resulted in a reduction in OGDH protein levels. Finally, through the investigation of the ubiquitin-mediated degradation pathway of OGDH, it was demonstrated that ANGPT2 inhibited the protein degradation of OGDH via deubiquitination, thereby maintaining its stability. In summary, UL82 promotes CRC cell proliferation by upregulating ANGPT2, which inhibits the ubiquitin-mediated degradation of OGDH, suggesting that targeting the UL82/ANGPT2/OGDH axis may offer a potential clinical strategy for the diagnosis of CRC.

Indexed as

Angiopoietin-2Colorectal NeoplasmsCytomegalovirusCytomegalovirus InfectionsViral ProteinsAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceUbiquitinationAngiopoietin-2ANGPT2 protein, humanViral ProteinsANGPT2Cell proliferationOGDHUL82

Identifiers

PMID40571161
PMCPMC12791878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.