Evidence map›Paper›PMID 40571094›Full record

ArticleThe Journal of pediatrics2025

Neonatal Neuroimaging Among Children Born Extremely Preterm and Motor Coordination Impairment at School-Age.

Susan R Hintz, Carla M Bann, Betty R Vohr, Elisabeth C McGowan, Yvonne E Vaucher, Martha G Fuller, Abhik Das, Deanne E Wilson-Costello, Donna M Garey, Cecelia Keller Sibley and 2 more

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Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Susan R HintzDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA. Electronic address: srhintz@stanford.edu.
Carla M BannSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
Betty R VohrDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI.
Elisabeth C McGowanDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI.
Yvonne E VaucherDepartment of Pediatrics, University of California at San Diego, San Diego, CA.
Martha G FullerDepartment of Pediatrics, University of California at San Diego, San Diego, CA; Hahn School of Nursing and Health Science, University of San Diego, San Diego, CA.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
Deanne E Wilson-CostelloDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
Donna M GareyDepartment of Pediatrics, University of California at San Diego, San Diego, CA; Division of Neonatology, Phoenix Children's Hospital, Phoenix, AZ.
Cecelia Keller SibleyDepartment of Pediatrics, Tufts University School of Medicine, Boston, MA.
Rosemary D HigginsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Research and Sponsored Programs, Florida Gulf Coast University, Fort Myers, FL.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD034216 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 1996 to 2015
$6.4M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027880 · NICHD · STANFORD UNIVERSITY · PI VAN MEURS, KRISA PAGE · 1991 to 2015
$6.1M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021364 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI WALSH, MICHELE · 1991 to 2015
$6.1M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027856 · NICHD · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SOKOL, GREGORY M. · 1991 to 2015
$5.9M
NCRR NIH HHS UL1 RR025008NCRR NIH HHS UL1 RR025744NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD068263NICHD NIH HHS U24 HD095254
6 · The paper itself

Abstract

objectivesTo examine, among children born extremely preterm, initial and late cranial ultrasound (CUS) findings and magnetic resonance imaging (MRI) findings of the brain at near term, including white matter abnormalities (WMA) as markers for motor coordination impairment at school age. STUDY

designThis was a prospective, longitudinal study of neonatal CUS and conventional MRI at near term among infants born 24-27

resultsTotal test score on MABC-2 was available for 320 children. Nearly 1 in 3 children had significant motor impairment, with rates increasing with decreasing EGA (24 weeks: 41%; 25 weeks: 41%; 26 weeks: 31%; 27 weeks: 21%). Greater rates of impairment were seen with adverse late CUS findings and increasing WMA severity, but importantly, high rates also were seen among those with normal late CUS (29%) and without WMA on MRI (22%). Motor impairment was independently associated with adverse late CUS in the group overall (aOR 5.00, 95% CI 1.53-16.29) and with moderate-severe WMA among those without CP (aOR 2.29, 95%CI 1.08-4.87).

conclusionsAlthough motor coordination impairment was associated with abnormal neonatal neuroimaging, there was a high prevalence among all infants born extremely preterm, whether with or without neuroimaging abnormalities. These findings indicate the need for consistent long-term follow-through and intervention.

Indexed as

BrainInfant, Extremely PrematureMagnetic Resonance ImagingMotor Skills DisordersNeuroimagingChildEchoencephalographyFemaleGestational AgeHumansInfant, NewbornLongitudinal StudiesMaleProspective Studiesbrain imagingdevelopmental coordination disorderextreme prematurityneurodevelopmental outcome

Identifiers

PMID40571094
PMCPMC12232903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.