Evidence map›Paper›PMID 40570852›Full record

ArticleImmunity2025

DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis.

Erin Janssen, Mrinmoy Das, Jordan Butts, Mohammed Alasharee, Saikat Mukherjee, Gabriel L Lozano, Chitong Rao, Andrew F Livingston, Brian Woods, Emma Smith and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026
    Review
  2. Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026
    Article
  3. DOCK8 in immune cells: roles and mechanisms.Frontiers in immunology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Erin JanssenDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Rheumatology, Department of Pediatrics, Michigan Medicine, Ann Arbor, MI 48109, USA. Electronic address: ejanssen@med.umich.edu.
Mrinmoy DasDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India.
Jordan ButtsDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mohammed AlashareeDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Saikat MukherjeeDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Gabriel L LozanoDivision of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Chitong RaoDivision of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Andrew F LivingstonDivision of Rheumatology, Department of Pediatrics, Michigan Medicine, Ann Arbor, MI 48109, USA.
Brian WoodsDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Emma SmithDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Zachary PetersDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Elena MilinDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Maria A BeamerDivision of Rheumatology, Department of Pediatrics, Michigan Medicine, Ann Arbor, MI 48109, USA.
Hazel WilkieDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 OAW, UK.
Juan-Manuel Leyva-CastilloDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Christy KamDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Ali SobhDepartment of Pediatrics, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Majed DasoukiDepartment of Genetics & Genomics, AdventHealth Medical Group Genomics and Personalized Health at Orlando, Orlando, FL 32803, USA.
Rima Hanna WakimDepartment of Pediatrics and Adolescent Medicine, Faculty of Medicine and Center for Infectious Diseases Research (CIDR), American University of Beirut, Beirut 1107 2020, Lebanon.
Ghassan DbaiboDepartment of Pediatrics and Adolescent Medicine, Faculty of Medicine and Center for Infectious Diseases Research (CIDR), American University of Beirut, Beirut 1107 2020, Lebanon.
Waleed Al-HerzDepartment of Pediatrics, Allergy and Clinical Immunology Unit, Al-Sabah Hospital, Department of Pediatrics, College of Medicine, Kuwait University, Kuwait City 13009, Kuwait.
Talal A ChatilaDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Fred D FinkelmanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Seth Rakoff-NahoumDivision of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Raif S GehaDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: raif.geha@childrens.harvard.edu.

Funding

Immunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9M
Targeting microbial dysbiosis in Food Allergy to restore toleranceR01AI158814 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, RAKOFF-NAHOUM, SETH · 2021 to 2025
$3.0M
Molecular and cellular mechanisms in food anaphylaxisR01AI153257 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI126915NIAID NIH HHS R01 AI153257NIAID NIH HHS R01 AI158814
6 · The paper itself

Abstract

Immunoglobulin E (IgE)-mediated release of mediators from mast cells (MCs) drives food allergy, and intestinal MC load is an important determinant of disease severity. Dedicator of cytokinesis 8 (DOCK8)-deficient patients are highly susceptible to food allergy. We found that they exhibited elevated serum MC tryptase levels, suggesting increased MC load. Dock8

Indexed as

AnaphylaxisFood HypersensitivityGuanine Nucleotide Exchange FactorsIntestinal MucosaMast CellsTh17 CellsT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalDisease SusceptibilityHumansImmunoglobulin EMiceMice, Inbred C57BLMice, KnockoutTryptasesDock8 protein, mouseGuanine Nucleotide Exchange FactorsImmunoglobulin ETryptasesanaphylaxisDOCK8dysbiosisfood allergyIL-4intestinal microbiomemast cellspassive anaphylaxisregulatory T cellstryptase

Identifiers

PMID40570852
PMCPMC12443339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.