ArticleImmunity2025
Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8
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In one paragraph
Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control.Frontiers in microbiology · 2026Review
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Enhancing cancer vaccine efficacy via electrostatic engineering of an FcγR-targeted protein.Frontiers in immunology · 2026Article
Corrections and comments
- Update of
Authors and funding
17 authors.
Verena van der HeideMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA. Electronic address: verena.vanderheide@mssm.edu.
Gabriel LaghlaliDepartment of Microbiology, ISMMS, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, ISMMS, New York, NY 10029, USA; Department of Pharmaceutics, Ghent University, 9000 Ghent, Belgium.
Bennett DavenportMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Beatrice CubittDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Vladimir RoudkoMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Human Immune Monitoring Center, ISMMS, New York, NY 10029, USA.
Daniel ChooEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Kevin JhunMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Etienne HumblinMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Abishek VaidyaMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Krista AngeliadisHuman Immune Monitoring Center, ISMMS, New York, NY 10029, USA.
Travis DawsonHuman Immune Monitoring Center, ISMMS, New York, NY 10029, USA.
Glaucia FurtadoMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Alice O KamphorstMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Department of Oncological Sciences, ISMMS, New York, NY 10029, USA; Tisch Cancer Institute, ISMMS, New York, NY 10029, USA.
Michael SchotsaertMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Department of Microbiology, ISMMS, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, ISMMS, New York, NY 10029, USA; Icahn Genomics Institute, ISMMS, New York, NY 10029, USA.
Rafi AhmedEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.
Juan Carlos de la TorreDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dirk HomannMarc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Diabetes, Obesity and Metabolism Institute, Department of Medicine, ISMMS, New York, NY 10029, USA. Electronic address: dxh2185@miami.edu.
Funding
Combined adjuvant approaches for enhancement of SARS-CoV-2 vaccine efficacyR01AI160706 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHOTSAERT, MICHAEL, WONG, PAMELA TINMOI · 2022 to 2025
$2.9MMolecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3MTRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007792 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CHO, JUDY H. · 2001 to 2016
$2.3MRegulation of Pathogen-specific T Cell Immunity by Adenosine GenerationR01AI093637 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOMANN, DIRK · 2012 to 2016
$2.0M7HP349, an oral integrin activator to augment effectiveness of pre-exposure influenza vaccinationR44AI176894 · NIAID · 7 HILLS PHARMA, LLC · PI DE, SIDDHARTHA, MARATHI, UPENDRA · 2023 to 2024
$1.9MT Cell Memory to VirusesR01AI186330 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2024 to 2026
$1.9MRoles of the Nucleoprotein 3'-5' Exonuclease Domain in Arenavirus BiologyR01AI142985 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C., MARTINEZ-SOBRIDO, LUIS · 2019 to 2022
$1.8MExperimental and natural SARS-CoV-2 infection of the human pancreasR01DK130425 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HOMANN, DIRK, SCHOTSAERT, MICHAEL · 2021 to 2023
$1.3MA General Molecular Strategy for Attenuation of Human Pathogenic ArenavirusesR21AI121840 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2016 to 2017
$529kDesigning mammarenavirus live vaccines with unbreachable attenuationR21AI169789 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2022 to 2023
$488kImpact of mucosal adjuvanted vaccines on virus transmission in preclinical animal models for SARS-CoV-2 and influenza virus infectionR21AI180874 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHOTSAERT, MICHAEL, WONG, PAMELA TINMOI · 2024 to 2025
$472kAdjuvant strategies for universal and multiseasonal influenza vaccine candidates in the context of pre-existing immunityR21AI176069 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHOTSAERT, MICHAEL, WONG, PAMELA TINMOI · 2023 to 2024
$466kNIAID NIH HHS R01 AI093637NIAID NIH HHS R01 AI142985NIAID NIH HHS R01 AI160706NIAID NIH HHS R01 AI186330NIAID NIH HHS R21 AI121840NIAID NIH HHS R21 AI169789NIAID NIH HHS R21 AI176069NIAID NIH HHS R21 AI180874NIAID NIH HHS R44 AI176894NIAID NIH HHS T32 AI052066NIDDK NIH HHS R01 DK130425NIDDK NIH HHS T32 DK007792
Abstract
Generation of functional memory CD8
Indexed as
Antigen PresentationCD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsAnimalsCell DifferentiationHepatocyte Nuclear Factor 1-alphaLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseacute infectionCD4(+) T cell helpCD8(+) T cell memory“helpless” memoryinfluenza A virusListeria monocytogeneslymphocytic choriomeningitis virusvaccinia virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.