ArticleCell genomics2025
Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal.
Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Cell Atlas of Adult Aedes aegypti Midgut Revealed by Single Nucleus/Cell RNA Sequencing.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Single-cell RNA sequencing unravels mosquito biology and host-pathogen interactions.Parasites & vectors · 2026Review
- Vector competence acrossJournal of virology · 2026Review
- Immune-reproductive cross talk in mosquitoes: molecular pathways and energy homeostasis.Parasites & vectors · 2026Review
- Transcriptional response of spermathecal secretory cells to mating and receipt of seminal fluid proteins iniScience · 2026Article
- Cell-specific responses of Anopheles gambiae fat body to blood feeding and infection at single-nuclei resolution.Nature communications · 2026Article
- Ecological and engineered modulation of the mosquito microbiome: mechanisms, vector competence, and translational prospects for disease control.Frontiers in microbiology · 2026Review
- Developmental regulation of intestinalbioRxiv : the preprint server for biology · 2025Article
- Article
- Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut.PLoS pathogens · 2025Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- Optimized Midgut Tissue Dissociation of Mosquitoes and Sandflies for High-Quality Single-Cell RNA Sequencing.Bio-protocol · 2025Article
- A look back at the Virology Departmental Days of the Institut Pasteur (Le Touquet, May 13-15, 2024).Journal of molecular cell biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aedes aegypti mosquitoes transmit arboviruses that pose a growing global health threat. After a bloodmeal, mosquitoes experience complex physiological changes orchestrated by the midgut and fat body, beginning with digestion and culminating in egg production. Our study provides comprehensive midgut and fat-body cell atlases using single-cell RNA sequencing and metabolomics. Our analyses reveal highly diverse cell populations specialized in digestion, metabolism, immunity, and reproduction. The midgut primarily comprises enterocytes, enteroendocrine, and intestinal stem cells, while the fat body features trophocytes and oenocytes but also a substantial hemocyte population and a newly found fat-body-yolk cell population. Additionally, Phasi Charoen-like virus was detected in midgut cells 7 days post bloodmeal. These findings highlight the complexity of mosquito abdominal tissues and inform the development of refined vector-control strategies, focusing on specific cell populations and metabolic pathways essential for mosquito reproductive success.
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