Evidence map›Paper›PMID 40570746›Full record

ArticleVaccine2025

Immunization with full-length TprC variants induces a broad response to surface-exposed epitopes of the Treponema pallidum repeat protein family and is partially protective in the rabbit model of syphilis.

Lorenzo Giacani, Emily Romeis, Austin Haynes, Barbara J Molini, Lauren C Tantalo, Linda H Xu, Aldo T Trejos, Jessica Keane, Zakriye Mohamed, Thaddeus D Armstrong and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The Global Syphilis Epidemic: Turning the Tide.Sexually transmitted diseases · 2026
    Article
  3. Article
  4. Article
  5. Lineage-specificbioRxiv : the preprint server for biology · 2026
    Article
  6. Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lorenzo GiacaniDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA. Electronic address: giacal@uw.edu.
Emily RomeisDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: eromeis@uw.edu.
Austin HaynesDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: amhaynes@uw.edu.
Barbara J MoliniDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: bjmolini@uw.edu.
Lauren C TantaloDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: ltantalo@uw.edu.
Linda H XuDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: lhx08@uw.edu.
Aldo T TrejosDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA. Electronic address: atrejos2@uw.edu.
Jessica KeaneDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: jessica.keane@yale.edu.
Zakriye MohamedDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: zmoham@uw.edu.
Thaddeus D ArmstrongDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: tarmst@uw.edu.
Benjamin A WielandDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: baw24@uw.edu.
Quynh PhungDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: quynh.phung@wsu.edu.
Dariia VyshenskaDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: dvysh@uw.edu.
Victoria L CampbellDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: vlc32@uw.edu.
Charmie GodornesDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: charmie@uw.edu.
David M KoelleDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA; Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Benaroya Research Institute, 1201 9th Ave, Seattle, WA 98101, USA. Electronic address: dkoelle@medicine.washington.edu.
Tara B ReidDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: tbrinck@uw.edu.
Yang WangVIB-VUB Center for Structural Biology, VIB, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yang.wang2@vub.be.
Anastassia A VorobievaVIB-VUB Center for Structural Biology, VIB, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: anastassia.andreevna.vorobieva@vub.be.
Anna WaldDepartment of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: annawald@uw.edu.
Nicole A P LiebermanDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: naliebe@uw.edu.
Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Electronic address: agrening@uw.edu.

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum InfectionU19AI144133 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 2019 to 2023
$10.6M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
NIAID NIH HHS T32 AI007140NIAID NIH HHS T32 AI007509NIAID NIH HHS U19 AI144133
6 · The paper itself

Abstract

An effective vaccine against syphilis could aid current control measures to reduce the incidence of infection. Protective immunity from the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), is associated with pathogen clearance by phagocytosis, supporting that immunization with an effective vaccine candidate should elicit opsonic antibodies to key epitopes at the host-pathogen interface. The T. pallidumrepeat (Tpr) proteins are putative β-barrel outer membrane porins with ten predicted extracellular loops. Here, we immunized three groups of eight rabbits with either a combination of three recombinant variants of the full-length TprC antigen, the TprD

Indexed as

Antigens, BacterialBacterial ProteinsBacterial VaccinesEpitopesPorinsSyphilisTreponema pallidumAnimalsAntibodies, BacterialDisease Models, AnimalFemaleImmunizationRabbitsAntibodies, BacterialAntigens, BacterialBacterial ProteinsBacterial VaccinesEpitopesPorinsB cell epitope mappingPhIP-SeqSyphilisT cell epitope mappingTprCTprD(2)TprKTreponema pallidumVaccine

Identifiers

PMID40570746
PMCPMC12455497

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.