ArticleArchives of oral biology2025
Effects of dentinogenesis imperfecta, sex, and tooth type on the compositional and structural organization of the dentin-enamel junction in the osteogenesis imperfecta murine model.
Article in Archives of oral biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveThis study investigates the structural and compositional features of the dentin-enamel junction in the osteogenesis imperfecta murine teeth, focusing on the effects of dentinogenesis imperfecta, sex, and tooth type.
designThe study compares dentin-enamel junctions in molars and incisors, as these teeth experience different functions and growth patterns, using a multiscale approach that combines micro-computed tomography (micro-CT), Scanning Electron Microscopy (SEM), and Raman Spectroscopy techniques.
resultsThe width of the mantle dentin is significantly reduced in dentinogenesis imperfecta-affected mice. Female mice show significantly larger gradients in mineral content and structural dentin-enamel junction than male mice. Molars have larger gradient widths compared to incisors. Molars exhibit higher dentin porosity and a smaller mantle dentin width compared to incisors.
conclusionDentinogenesis imperfecta causes a decrease in tubule diameter and an increase in the number of tubules, which may contribute to heightened tooth sensitivity in dentinogenesis imperfecta-affected mice. Females may have better resilience to stress and fractures, potentially explaining why dentinogenesis imperfecta might be diagnosed more frequently in males. Larger gradient widths in molars may help protect them due to their different functions and mechanical stresses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.