Evidence map›Paper›PMID 40570369›Full record

ArticleCell reports2025

A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency.

Berenice Cabrera-Martinez, Josselyn E Garcia-Perez, Ryan M Baxter, Victor G Lui, Tusharkanti Ghosh, Ahmet Eken, Zander Kostka-Newman, John Rhey Mhar Garcia, Jeremy Rahkola, Rachel L Gessner and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Berenice Cabrera-MartinezDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Josselyn E Garcia-PerezDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA; CellCarta, Leuven, Belgium.
Ryan M BaxterDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Victor G LuiDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA; Benaroya Research Institute, Seattle, WA, USA.
Tusharkanti GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Ahmet EkenDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Zander Kostka-NewmanDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
John Rhey Mhar GarciaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Jeremy RahkolaRocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, USA.
Rachel L GessnerMedicine-Hematology, University of Colorado School of Medicine, Aurora, CO, USA.
Cullen M DutmerDepartment of Pediatrics, Section of Allergy and Immunology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA.
Jared KlarquistDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Eric M PietrasMedicine-Hematology, University of Colorado School of Medicine, Aurora, CO, USA.
Debashis GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Sara A JohnsonDepartment of Pediatrics, Section of Allergy and Immunology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA.
Ross M KedlDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Elena W Y HsiehDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Pediatrics, Section of Allergy and Immunology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA. Electronic address: elena.hsieh@cuanschutz.edu.

Funding

Transcriptional regulation of vaccine-elicited and infection-elicited CD8+ T cell responsesR01AI066121 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Ross M Kedl · 2007 to 2026
$7.1M
Molecular and cellular basis of Combined Adjuvant-Elicited Cellular ImmunityR01AI126899 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2016 to 2020
$2.5M
CD8 T cell and B cell collaboration following subunit vaccinationR01AI148919 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2020 to 2023
$2.0M
Immune Dysregulation in Pediatric SLE PathogenesisK23AR070897 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HSIEH, WEN-YUAN E · 2017 to 2021
$850k
NIAID NIH HHS R01 AI066121NIAID NIH HHS R01 AI126899NIAID NIH HHS R01 AI148919NIAMS NIH HHS K23 AR070897
6 · The paper itself

Abstract

Here, we describe the use of a homologous knockin mouse model to further decipher the mechanism(s) of a novel human homozygous IL2RB hypomorphic mutation. Our model recapitulates the human immune dysregulation phenotype, showing decreased mutant interleukin-2Rβ (IL-2Rβ) cell-surface expression, impaired IL-2/15-dependent STAT5 signaling, elevated serum IL-2/15 levels, expanded effector memory CD8

Indexed as

Interleukin-2 Receptor beta SubunitMutationAnimalsAutoimmunityCD8-Positive T-LymphocytesDisease Models, AnimalHumansInterleukin-15Interleukin-2MiceMice, Inbred C57BLSignal TransductionSTAT5 Transcription FactorT-Lymphocytes, RegulatoryIl2rb protein, mouseInterleukin-15Interleukin-2Interleukin-2 Receptor beta SubunitSTAT5 Transcription FactorCD8 T cellsCP: ImmunologyIEIIL-15IL-2IL-2Rβinborn errors of immunitypro-inflammatory cytokinesregulatory T cellsSTAT5 signalingTregs

Identifiers

PMID40570369
PMCPMC12352292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.