Evidence map›Paper›PMID 40570199›Full record

ArticleThe Journal of infectious diseases2026

Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool.

Charles Ssuuna, Hridesh Mishra, Michael T Hawkes, Veselina Stefanova, Aleksandra Leligdowicz, Michael Lintner-Rivera, Anthony Batte, Kathleen Zhong, Sophie Namasopo, Robert O Opoka and 2 more

Abstract read
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In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Charles SsuunaCHILD Laboratory, Global Health Uganda, Kampala, Uganda.
Hridesh MishraDepartment of Medicine, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8572-2736
Michael T HawkesDepartment of Pediatrics, British Columbia Children's Hospital, University of British Colombia, Vancouver, British Columbia, Canada.ORCID 0000-0002-4122-0937
Veselina StefanovaDepartment of Medicine, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Aleksandra LeligdowiczDepartment of Medicine, Division of Critical Care, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Michael Lintner-RiveraRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-8855-6745
Anthony BatteCHILD Laboratory, Global Health Uganda, Kampala, Uganda.ORCID 0000-0001-7463-5277
Kathleen ZhongDepartment of Medicine, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Sophie NamasopoDepartment of Pediatrics, Kabale Regional Referral Hospital, Kabale, Uganda.ORCID 0000-0002-8895-0144
Robert O OpokaAga Khan University, Nairobi, Kenya.
Kevin C KainDepartment of Medicine, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-6068-1272
Andrea L ConroyCHILD Laboratory, Global Health Uganda, Kampala, Uganda.ORCID 0000-0002-5328-6511

Funding

Canada Research ChairsCanadian Institutes of Health Research (CIHR) FDN-148439Kim KertlandRotary InternationalTesari FoundationWomen and Children's Health Research Institute
6 · The paper itself

Abstract

Soluble urokinase-type plasminogen activator receptor (suPAR) is an emerging critical illness biomarker. Circulating suPAR levels are elevated in severe malaria and are associated with mortality risk. The present study evaluated clinical predictors of elevated plasma suPAR (≥15 ng/mL). Elevated suPAR occurred in 22.1% of 1226 Ugandan children with severe malaria and was independently associated with severe acute kidney injury, hyperlactatemia, and coma, as well as biomarkers of immune and endothelial activation. An optimized clinical decision algorithm that prioritizes suPAR testing for children with clinical danger signs, including coma and kidney injury, could improve the identification of children at highest risk of death.

Indexed as

MalariaReceptors, Urokinase Plasminogen ActivatorAcute Kidney InjuryBiomarkersChildChild, PreschoolFemaleHospitalizationHumansInfantMaleRisk AssessmentUgandaBiomarkersPLAUR protein, humanReceptors, Urokinase Plasminogen Activatoracute kidney injurycomamortalitysevere malariasuPAR

Identifiers

PMID40570199
PMCPMC12811883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.