Evidence map›Paper›PMID 40570180›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2025

Pilot Trial of a Behavioral Economics-Informed Clinical Decision Support Alert to Improve Inpatient Tobacco Use Treatment Rates.

Robert Schnoll, Daniel Blumenthal, E Paul Wileyto, Anna-Marika Bauer, Sarah Evers-Casey, Nathaniel Stevens, Tierney Fisher, Sue Ware, Brian P Jenssen, Colin Wollack and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04738643 (Improving Tobacco Treatment Rates for Cancer Patients Who Smoke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04738643 nacompletednot on this map

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

TypeinterventionalSponsorAbramson Cancer Center at Penn MedicineRan2022 to 2024Enrolled685ConditionsCancer, Tobacco Use, Smoking, Nicotine DependenceArmsTobacco Use Treatment Service and Varenicline Management
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Robert SchnollDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-4089-856X
Daniel BlumenthalDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
E Paul WileytoCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Anna-Marika BauerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sarah Evers-CaseyComprehensive Smoking Treatment Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Nathaniel StevensDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Tierney FisherComprehensive Smoking Treatment Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sue WareDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Brian P JenssenDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-6082-4931
Colin WollackPenn Medicine, University of Pennsylvania, Philadelphia, PA.
Spencer SchwartzDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Frank T LeoneComprehensive Smoking Treatment Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Funding

A Patient-Oriented Research Mentoring Program in Tobacco Dependence ResearchK24DA045244 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Robert Adam Schnoll · 2018 to 2026
$1.7M
Commonwealth of Pennsylvania Department of Health 4100083101NIDA NIH HHS K24 DA045244
6 · The paper itself

Abstract

introductionEvidence-based tobacco use treatment (TUT) improves clinical outcomes, yet few clinicians initiate TUT for hospitalized patients who smoke. Clinical decision support (CDS) tools embedded in electronic health records (EHRs) offer opportunities to guide clinicians toward desired behaviors. CDS alerts informed by behavioral economics (BE-CDS) may increase TUT by presenting preselected orders and requiring justification to opt out. We conducted a pilot study to evaluate the impact of a BE-CDS alert on TUT ordering for inpatients who smoke. AIMS AND

methodsIn a two-arm randomized trial at a large US academic health system, 50 clinicians were randomized to receive either a BE-CDS alert or a standard reminder encouraging inpatient pharmacotherapy and outpatient follow-up. Alerts were triggered upon chart entry for eligible patients. The primary outcome was the rate of any TUT-related order (medication, counseling, or referral). Clinician feedback on alert appropriateness and workflow impact was also collected.

resultsFrom June 2022 to December 2023, 635 inpatients met the inclusion criteria. There were no significant differences in rates of any TUT order (25.2% vs. 28.5%, p = .27), inpatient medication (17.2% vs. 18.4%, p = .62), or discharge medication (7.1% vs. 6.6%, p = .90). Referral to outpatient follow-up was higher in the BE-CDS group (8.4% vs. 3.3%; OR = 2.54, p = .01). Number of alerts delivered, and White patient race, were associated with increased TUT rates. Clinicians preferred the BE-CDS format but cited alert workflow placement as more influential than alert design.

conclusionsBE-CDS improved referral rates but did not significantly impact overall TUT. Further research should explore deeper drivers of inpatient TUT decision-making.

trial registrationClinicalTrials.gov. NCT04738643. Registered February 4, 2021. https://clinicaltrials.gov/study/NCT04738643. IMPLICATIONS: Compared to the standard electronic practice reminders, behavioral economics-informed clinical decision support alerts increased referrals to outpatient tobacco use treatment services for inpatients who smoke, but did not increase tobacco treatment intervention rates during the inpatient stay. Several variables appear to influence rates of tobacco use treatment, including the number of alert interactions and patient race. This pilot study suggests that the barriers to inpatient tobacco interventions may be complex and therefore insensitive to simple behavioral economic nudges.

Indexed as

Decision Support Systems, ClinicalEconomics, BehavioralInpatientsSmoking CessationTobacco UseAdultElectronic Health RecordsFemaleHumansMaleMiddle AgedPilot Projects

Identifiers

PMID40570180
PMCPMC13396255

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.