Evidence map›Paper›PMID 40570033›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Blood Retention and Kidney Clearance of Renal-Clearable Gold Nanoparticles Strongly Correlate with Renal Injury Biomarkers.

Samira Ahrari, Yi Luo, Xuhui Ning, Qi Cai, Nilum Rajora, Ramesh Saxena, Mengxiao Yu, Jie Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samira AhrariDepartment of Chemistry and Biochemistry, The University of Texas at Dallas Richardson, Texas, 75080, USA.
Yi LuoDepartment of Chemistry and Biochemistry, The University of Texas at Dallas Richardson, Texas, 75080, USA.
Xuhui NingDepartment of Chemistry and Biochemistry, The University of Texas at Dallas Richardson, Texas, 75080, USA.
Qi CaiDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Nilum RajoraDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Ramesh SaxenaDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Mengxiao YuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas Richardson, Texas, 75080, USA.
Jie ZhengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas Richardson, Texas, 75080, USA.ORCID 0000-0001-8546-1882

Funding

Glomerular Filtration of Sub-nm Gold NanoparticlesR01DK115986 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2018 to 2021
$1.4M
Unravel Nanoparticle Transport and Interactions in Renal Proximal TubulesR01DK124881 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI YU, MENGXIAO · 2020 to 2024
$1.4M
NIDDK NIH HHS R01 DK124881NIH HHS R01DK115986NIH HHS R01DK124881
6 · The paper itself

Abstract

Renal-clearable engineered nanoparticles are typically filtered through the glomeruli and transported along the renal tubules before entering the bladder. However, the effects of glomerular leakage and tubular injury, two common features of kidney diseases, on nanoparticle transport remain poorly understood. Herein, we investigated the blood retention, kidney accumulation, and renal clearance of Au₂₅(SG)₁₈ in a doxorubicin-induced acute kidney injury (AKI) mouse model. By correlating its transport with proteinuria and urinary kidney injury molecule-1 (KIM-1), endogenous biomarkers of glomerular leakage and proximal tubular injury, respectively, we found that glomerular leakage, as indicated by a >50-fold increase in proteinuria, did not enhance its blood clearance. Instead, tubular injury significantly reduced glomerular filtration, resulting in elevated blood retention, increased kidney accumulation, and reduced renal clearance of Au₂₅(SG)₁₈. Moreover, Au₂₅(SG)₁₈ blood retention exhibited a very strong positive correlation with urinary KIM-1 (Pearson's coefficient r = 0.90), much stronger than KIM-1 correlations with conventional glomerular filtration blood markers such as serum creatinine. This suggests that Au₂₅(SG)₁₈ could serve as a sensitive exogenous blood marker of tubular injury, expanding the diagnostic potential of renal-clearable nanoparticles in kidney diseases.

Indexed as

Acute Kidney InjuryGoldKidneyMetal NanoparticlesAnimalsBiomarkersDoxorubicinHepatitis A Virus Cellular Receptor 1MaleMiceMice, Inbred C57BLBiomarkersDoxorubicinGoldHavcr1 protein, mouseHepatitis A Virus Cellular Receptor 1CorrelationGlomerular injuryKidney disease biomarkersNanoparticlesProximal tubular injury

Identifiers

PMID40570033
PMCPMC12978759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.