ArticleLeukemia & lymphoma2025
Changes in first-line treatment patterns according to frailty in chronic lymphocytic leukemia/small lymphocytic lymphoma.
Article in Leukemia & lymphoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Novel therapies have transformed treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), but how they have changed treatment for frail patients is unclear. Using Surveillance, Epidemiology, and End Results-Medicare data, we conducted a nested case-control analysis to evaluate the influence of frailty, measured with Function-Related Indicators (FRIs), on first-line treatment initiation. Four FRIs were positively associated and seven were negatively associated with treatment initiation, representing CLL/SLL symptoms and general frailty, respectively. During the chemoimmunotherapy era (2006-2013), patients with general frailty were significantly less likely to initiate treatment (aOR for 1 FRIs: 0.86, 95% CI 0.77-0.96; 2 FRIs: 0.83, 95% CI 0.70-0.98; ≥3 FRIs: 0.55, 95% CI 0.0.44-0.68 versus 0 FRIs). By 2019, this relationship diminished (p
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