Evidence map›Paper›PMID 40569582›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.

Natasha G Boyes, Dain W Jacob, Brian Shariffi, Anna M Gonsalves, Jennifer L Harper, Brian P Bostick, Jacqueline K Limberg

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natasha G BoyesDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0009-0007-3471-9012
Dain W JacobDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0003-4344-3250
Brian ShariffiDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0009-0009-1821-6428
Anna M GonsalvesDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0009-0007-9123-904X
Jennifer L HarperDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0009-0004-5871-1507
Brian P BostickDivision of Cardiovascular Medicine, Department of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-5628-0249
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-9982-5851

Funding

Sex disparities in hypoxic sympatholysis and impact of obesityR01HL153523 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2020 to 2024
$2.7M
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesR00HL130339 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2017 to 2019
$729k
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesK99HL130339 · NHLBI · MAYO CLINIC ROCHESTER · PI LIMBERG, JACQUELINE K · 2016 to 2017
$156k
HHS | National Institutes of Health (NIH) HL130339HHS | National Institutes of Health (NIH) HL153523NHLBI NIH HHS K99 HL130339NHLBI NIH HHS R00 HL130339NHLBI NIH HHS R01 HL153523
6 · The paper itself

Abstract

Sympathetic-mediated vasoconstriction is attenuated during hypoxia in young women with normal weight (NW) (i.e., hypoxic sympatholysis). Obesity is associated with exaggerated sympathetic nervous system activity that may augment sympathetic vasoconstriction and impair hypoxic sympatholysis. We hypothesized that hypoxic sympatholysis would be attenuated in women with overweight (OW) and obesity compared with women with normal weight. Forearm blood flow (FBF, venous occlusion plethysmography), muscle sympathetic nerve activity (MSNA, peroneal microneurography), blood pressure (finger plethysmography), and arterial oxygen saturation ([Formula: see text], pulse oximetry) were measured in women with normal weight (NW;

Indexed as

HypoxiaObesityOverweightAdultBlood PressureCold TemperatureFemaleForearmHumansMuscle, SkeletalRegional Blood FlowSympathetic Nervous SystemVasoconstrictionYoung Adultfemaleforearm blood flowmuscle sympathetic nerve activityobesitysympathetic nervous system

Identifiers

PMID40569582
PMCPMC12278904

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.