Evidence map›Paper›PMID 40569543›Full record

ArticleGeroScience2026

The CAIDE dementia risk score indicates elevated cognitive risk in late adulthood: a structural and functional neuroimaging study.

Katalin Farkas, Timea Lazar, Melinda Becske, Janos Andras Zsuffa, Viktoria Rosenfeld, Dalida Borbala Berente, Gergo Bolla, Janos Negyesi, Andras Attila Horvath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katalin FarkasFaculty of Medicine, Semmelweis University, 26 Ulloi Ut, 1085, Budapest, Hungary.
Timea LazarSchool of PhD Studies, Semmelweis University, 26 Ulloi Ut, 1085, Budapest, Hungary.
Melinda BecskeSchool of PhD Studies, Semmelweis University, 26 Ulloi Ut, 1085, Budapest, Hungary.
Janos Andras ZsuffaNyiro Gyula National Institute of Psychiatry and Addictology, Neurocognitive Research Centre, 59-61 Lehel Utca, 1135, Budapest, Hungary.
Viktoria RosenfeldSchool of PhD Studies, Semmelweis University, 26 Ulloi Ut, 1085, Budapest, Hungary.
Dalida Borbala BerenteNyiro Gyula National Institute of Psychiatry and Addictology, Neurocognitive Research Centre, 59-61 Lehel Utca, 1135, Budapest, Hungary.
Gergo BollaSchool of PhD Studies, Semmelweis University, 26 Ulloi Ut, 1085, Budapest, Hungary.
Janos NegyesiNyiro Gyula National Institute of Psychiatry and Addictology, Neurocognitive Research Centre, 59-61 Lehel Utca, 1135, Budapest, Hungary.
Andras Attila HorvathNyiro Gyula National Institute of Psychiatry and Addictology, Neurocognitive Research Centre, 59-61 Lehel Utca, 1135, Budapest, Hungary. andras.horvath.semmelweis@gmail.com.ORCID 0000-0002-5614-7015

Funding

Magyar Tudományos Akadémia Lendulet-2023_94
6 · The paper itself

Abstract

While the CAIDE score is an established mid-life risk assessment tool for the longitudinal prediction of dementia, its application as a measure of elevated cognitive risk in late adulthood is unclear. One hundred one healthy individuals (aged > 55) were tested using detailed neuropsychological assessments, as well as structural and functional MRI. Participants were divided into a low-risk group (CAIDE < 7) and a high-risk group (CAIDE > 6). High-risk participants had significantly worse cognitive performance in the Trail-Making Test results (TMT-B: t = -4.03, p = 0.0001), and significantly smaller global brain volumes (e.g., brain segmentation volume: t = 2.898, p = 0.0485) and regional volumes (e.g., accumbens volumes: t

Indexed as

BrainCognitive DysfunctionDementiaFunctional NeuroimagingAgedCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsRisk AssessmentRisk FactorsBrain atrophyCAIDE scoreCognitive riskFunctional neuroimagingLate adulthoodNeuropsychology

Identifiers

PMID40569543
PMCPMC12972359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.