Evidence map›Paper›PMID 40569497›Full record

ArticleVirus genes2025

Elevated oncogene expressions in koala infected with multiple koala retrovirus subtypes: a preliminary study.

Lipi Akter, Md Abul Hashem, Mohammad Enamul Hoque Kayesh, Tofazzal Md Rakib, Md Haroon Or Rashid, Fumie Maetani, Kyoko Tsukiyama-Kohara

Erratum issuedAbstract read
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In one paragraph

Article in Virus genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lipi AkterTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan.
Md Abul HashemTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan.
Mohammad Enamul Hoque KayeshTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan.
Tofazzal Md RakibTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan.
Md Haroon Or RashidTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan.
Fumie MaetaniHirakawa Zoological Park, Kagoshima, 891-0133, Japan.
Kyoko Tsukiyama-KoharaTransboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan. kkohara@vet.kagoshima-u.ac.jp.

Funding

Ministry of Education, Science, and Culture, Japan
6 · The paper itself

Abstract

Koala retrovirus (KoRV) causes multiple disease phenotypes in koalas, including carcinogenesis. The study aimed to assess oncogene expression in spleen tissues from ten deceased koalas coinfected with different subtypes and peripheral blood mononuclear cells (PBMCs) from two subclinically coinfected koalas with KoRV-A and KoRV-B. Initially, KoRV subtyping involved amplifying endogenous KoRV-A, and exogenous KoRV-B, -C specific env gene fragments, followed by sequencing. Using quantitative real-time polymerase chain reaction (RT-qPCR), we examined five oncogenes (BCL2, BAX, BCL2L1, BCL3, and MYC) in spleen and PBMCs from dead and alive koalas coinfected with multiple KoRV subtypes, respectively. Significant (p < 0.05) increases in BCL2 and BAX oncogene expression were observed in deceased koalas that were coinfected with multiple KoRV subtypes compared with healthy koalas. Thus, this study highlights a potential link between KoRV subtype infections, oncogene expression, and koala diseases.

Indexed as

OncogenesPhascolarctidaeRetroviridaeRetroviridae InfectionsAnimalsLeukocytes, MononuclearSpleenBCL2KoRVLymphomaMYCOncogene

Identifiers

PMID40569497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.