Evidence map›Paper›PMID 40569448›Full record

ArticleLasers in medical science2025

Network meta-analysis of different modalities of intense pulsed light therapy in the treatment of dry eye disease induced by meibomian gland dysfunction.

Jing Cong, Yiting Wu, Chunqiong Dong, Yiwen Cheng, Xueqi Lin, Jiayue Yuan, Qianhong Feng, Shichu Liu, Jinhui Dai, Xiaoping Ma and 1 more

Abstract readNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing CongDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yiting WuDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Chunqiong DongDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yiwen ChengDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xueqi LinDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiayue YuanDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Qianhong FengDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shichu LiuDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jinhui DaiDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. dai.jinhui@zs-hospital.sh.cn.
Xiaoping MaDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. xiaopingma@126.com.
Xinyi XieDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. xie.xinyi@zs-hospital.sh.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis network meta-analysis aimed to evaluate the comparative effect of five different protocols of IPL treatment in treating MGD-related DED, including optimal pulse technology [OPT]-based IPL, E > eye-based IPL, OPT-based IPL plus meibomian gland expression (MGX), E > eye-based IPL plus MGX, Eyesis-based IPL plus MGX.

methodsPubMed, Embase, Cochrane Library, SCOPUS and China National Knowledge Infrastructure (CNKI) were searched for eligible studies published before November 10, 2022.

resultsRandom network meta-analysis was conducted to estimate the differences between different protocols of IPL treatment in ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED), tear break-up time (TBUT), meibomian gland quality (MGQ), meibomian gland evaluation (MGE), and corneal fluorescein staining (CFS). Rank probability showed OPT-based IPL plus MGX ranked first in OSDI and SPEED, E > eye-based IPL plus MGX ranked first in TUBT, MGQ, and CFS, but Eyesis-based IPL plus MGX ranked first in MGE.

conclusionsBased on available evidence, for individuals with MGD-related DED, OPT-based IPL plus MGX may be the preferred treatment protocol for relieving ocular symptoms, but E > eye-based IPL plus MGX may be more beneficial for improving ocular function.

Indexed as

Dry Eye SyndromesIntense Pulsed Light TherapyMeibomian Gland DysfunctionHumansMeibomian GlandsDry eye diseaseIntense pulsed lightMeibomian gland dysfunctionNetwork meta-analysis

Identifiers

PMID40569448

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.