ArticleEuropean archives of psychiatry and clinical neuroscience2025
Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.
Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious research has indicated a link between social or physical activity and suicide attempt (SA), yet the causal relationship remains unclear, and the role of psychiatric disorders has not been elucidated.
methodIn this study, we used genetic variants of social or physical activity to examine the causal associations with SA based on iPSYCH database, and then replicate the results using FinnGen database.
resultsWe found that sports clubs or gyms, walking for pleasure, light DIY and other exercises (e.g. bowling, swimming, cycling, and keep fit) may be protective factors for SA, while leisure/social inactivity may be risk factors. After FDR correction of P value, it was revealed that the OR [95%CI] of SA decreased per SD increase in walking for pleasure (0.23[0.07-0.73]), light DIY (0.21[0.07-0.59]), and other exercise (0.22[0.09-0.58]). Within the replication phase, genetic prediction analyses revealed that walking for pleasure, light DIY, and other exercises were associated with reduced susceptibility to SA (P
conclusionOur research findings highlight the protective effect of social/physical activity in SA, and elucidated that increasing light DIY and other exercise can be used as a prevention strategy of SA, particularly for individuals who have ADHD.
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