Evidence map›Paper›PMID 40569419›Full record

ReviewEuropean journal of applied physiology2025

The myth of the Bayesian brain.

Madhur Mangalam

Abstract readReview
In one paragraph

Review in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. The illusion of internal models in biological movement.European journal of applied physiology · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Madhur MangalamDivision of Biomechanics and Research Development, Department of Biomechanics, Center for Research in Human Movement Variability, Omaha, NE, 68182, USA. mmangalam@unomaha.edu.ORCID http://orcid.org/0000-0001-6369-0414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Bayesian brain hypothesis-the idea that neural systems implement or approximate Bayesian inference-has become a dominant framework in cognitive neuroscience over the past two decades. While mathematically elegant and conceptually unifying, this paper argues that the hypothesis occupies an ambiguous territory between useful metaphor and testable, biologically plausible mechanistic explanation. We critically examine the key claims of the Bayesian brain hypothesis, highlighting issues of unfalsifiability, biological implausibility, and inconsistent empirical support. The framework's remarkable flexibility in accommodating diverse findings raises concerns about its explanatory power, as models can often be adjusted post hoc to fit virtually any data pattern. We contrast the Bayesian approach with alternative frameworks, including dynamic systems theory, ecological psychology, and embodied cognition, which conceptualize prediction and adaptive behavior without recourse to probabilistic inference. Despite its limitations, the Bayesian brain hypothesis persists-driven less by empirical grounding than by its mathematical elegance, metaphorical power, and institutional momentum.

Indexed as

BrainModels, NeurologicalAnimalsBayes TheoremCognitionHumansBayesian brain hypothesisCognitive neuroscienceDynamic systems theoryEmbodied cognitionFree energy principlePhilosophy of neurosciencePredictive codingTheoretical neuroscienceUnfalsifiability

Identifiers

PMID40569419
PMCPMC12479598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.