Evidence map›Paper›PMID 40569380›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.

Gerald P Maeda, Vy Dang, Mary Katherine Kelly, Aadhunik Sundar, Ryan L W Arnott, Edward M Marcotte, Nancy A Moran

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gerald P MaedaDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-9123-9353
Vy DangDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Mary Katherine KellyDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712.
Aadhunik SundarDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712.
Ryan L W ArnottDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712.
Edward M MarcotteDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0001-8808-180X
Nancy A MoranDepartment of Integrative Biology, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-2983-9769

Funding

Proteomics and model organism humanization to decode human geneticsR35GM122480 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE · 2017 to 2026
$5.4M
Elucidating the molecular bases of species interactions in host-associated bacterial communitiesR35GM131738 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MORAN, NANCY A. · 2019 to 2023
$2.0M
DOD | USA | AFC | CCDC | Army Research Office (ARO) W911NF-12-1-0390NIGMS NIH HHS R35 GM122480NIGMS NIH HHS R35 GM131738Welch Foundation (The Welch Foundation) F-1515
6 · The paper itself

Abstract

Insects frequently form associations with maternally transmitted symbiotic bacteria. This transmission mode ensures that symbiont-conferred effects, both beneficial and negative, are passed onto offspring. Here, we report an extreme example of symbiont-mediated temperature sensitivity imposed by a vertically transmitted, defensive symbiont. Pea aphids infected with the bacterial endosymbiont,

Indexed as

Antifungal AgentsAphidsPeptidesSymbiosisAnimalsHot TemperaturePeptide SynthasesAntifungal Agentsnon-ribosomal peptide synthasePeptidesPeptide Synthasesantifungalaphiddefensive symbiosisFukatsuiatrade-off

Identifiers

PMID40569380
PMCPMC12232616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.