Evidence map›Paper›PMID 40569361›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Coactosin-Like Protein Reduces Prostaglandin D

Li-Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Coactosin-Like Protein Reduces Prostaglandin DAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li-Long PanMOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Zhengnan RenSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Binbin LiSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Wenjie LiangSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Yang LuoSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Qin YangSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
He LiuSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Xiaoliang DongSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Haizhi TianSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Huimin ZouSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Bengt SamuelssonDepartment of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, 17177, Sweden.
Olof RådmarkDepartment of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, 17177, Sweden.
Jia SunSchool of Food Science and Technology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.ORCID https://orcid.org/0000-0002-4874-1305

Funding

Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu ProvinceFundamental Research Funds for the Central Universities JUSRP124024Fundamental Research Funds for the Central Universities JUSRP202404001Fundamental Research Funds for the Central Universities JUSRP202406003Fundamental Research Funds for the Central Universities JUSRP22007Fundamental Research Funds for the Central Universities JUSRP221037MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic DiseasesNational Natural Science Foundation of China 32300746Natural Science Foundation of Jiangsu Province BK20231042Natural Science Foundation of Jiangsu Province BK20231047
6 · The paper itself

Abstract

Allergic asthma is a significant global health issue characterized by chronic airway inflammation. Current treatments only alleviate symptoms but fail to cure the disease due to its complex pathology. Lipid mediators from arachidonate metabolism are pivotal in immune regulation in asthma. Previously, coactosin-like protein (CLP) is identified as a regulator of leukotriene production in vitro. However, its role in asthma is unclear. In this study, it is found that CLP-deficient (Cotl1

Indexed as

AsthmaInflammationMacrophages, AlveolarProstaglandin D2AnimalsDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutPyroglyphidaeReceptors, ImmunologicReceptors, ProstaglandinProstaglandin D2Receptors, ImmunologicReceptors, Prostaglandinallergic asthmaalveolar macrophage polarizationchemoattractant receptor‐homologous molecule expressed on Th2 cellscoactosin‐like proteinprostaglandin D2

Identifiers

PMID40569361
PMCPMC12442705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.