ArticleBiotechnology letters2025
Optimizing hyaluronic acid production by Streptococcus zooepidemicus using taguchi method: effects of temperature and pH.
Article in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Optimization of hyaluronic acid production through co-culture of mutant Streptococcus zooepidemicus and Streptococcus pyogenes under controlled uv and environmental conditions.Bioprocess and biosystems engineering · 2026Article
- Comparative evaluation of glucosamine derivatives for enhanced microbial hyaluronic acid production by Streptococcus zooepidemicus and Streptococcus pyogenes.Archives of microbiology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The cost-effective and high-yield production of hyaluronic acid (HA) by microbial means remains challenging, necessitating the optimization of existing processes through the implementation of novel approaches. The present study investigates the production of HA under varying temperature and pH conditions utilizing independent, fully controlled fermenters. The synthesis of HA was evaluated at four temperatures (32 °C, 35 °C, 37 °C, 40 °C) and four pH levels (6.5, 7.0, 7.5, and 8.0), with optimal parameters identified through the Taguchi design methodology. The Taguchi optimization method effectively identified 37 °C and pH 6.5 as the optimal conditions for HA production corresponding to the highest signal-to-noise (S/N) ratios of 58.18 and 57.55, respectively. These conditions resulted in a maximum yield of 1.08 g.L
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