ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS-Initiated Neuroinflammation and BK Channel Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intratympanic injection of human umbilical cord mesenchymal stem cell derived small extracellular vesicles for refractory sudden sensorineural hearing loss: a Phase 1 trial.Stem cell research & therapy · 2026Article
- [Elucidating the gene-environment interplay in risk factors for Age-related hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Effects of polychlorinated biphenyls on the peripheral and central auditory systems.Hearing research · 2025Review
- Comparative Anatomical and Morphometric Analysis of Eustachian Tube Across Species.Audiology research · 2025Article
- NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.Frontiers in aging neuroscience · 2025Review
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Authors and funding
17 authors.
Funding
Abstract
Most patients with sensorineural hearing loss (SNHL) may initially experience high-frequency hearing loss linked to greater vulnerability of outer hair cells (OHCs) in the cochlear basal turn. However, the molecular mechanism underlying this susceptibility in the high-frequency region remains unclear. Here, NOX2 is first identified as a differentially expressed gene related to oxidative damage in the apical and basal turns through single-cell RNA sequencing. In mouse cochleae damaged by neomycin and noise, Nox2-positive OHCs increase progressively from the apex to base, indicating that NOX2 expression clearly differed significantly between the apical and basal OHCs. In NOX2 knockout mice, OHC damage caused by neomycin and noise exposure is significantly reduced. Furthermore, knocking out NOX2 increases the expression of Nrf2 in the cytoplasm and Nrf2 nuclear translocation in OHCs. In addition, Nrf2 inhibitors counteract the protective effect of NOX2 knockout against neomycin. Finally, when Nox2 is used as the target, ginsenoside Rg1 is identified as a compound with protective effects against neomycin-induced hearing loss. In summary, these results indicate NOX2 is highly correlated with high-frequency OHCs vulnerability in the cochlea and is a potential intervention target for the clinical treatment of SNHL.
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Registered trials
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