Evidence map›Paper›PMID 40569179›Full record

ArticleOrganic letters2025

General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via

Christopher M Hanneman, Sanghoon Song, Nicholas P R Onuska, J Craig Ruble, Shannon S Stahl

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pyridine-containing antitumor agents: structure-oriented medicinal chemistry, structure-activity relationships, and ADMET liabilities.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher M HannemanDepartment of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Sanghoon SongDepartment of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Nicholas P R OnuskaLilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
J Craig RubleLilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Shannon S StahlDepartment of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0002-9000-7665

Funding

Catalytic Redox Reactions for Pharmaceutical SynthesisR35GM134929 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Shannon S Stahl · 2020 to 2026
$4.3M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIGMS NIH HHS R35 GM134929NIH HHS S10 OD020022
6 · The paper itself

Abstract

Aldehyde oxidase (AO) contributes significantly to metabolism of drug molecules containing heteroaromatics, and the lack of synthetic mimics for AO-mediated reactivity is a barrier to drug development. Herein, we use tandem

Indexed as

Aldehyde OxidaseQuinolinesQuinolonesMolecular StructureOxidation-ReductionPharmaceutical PreparationsAldehyde OxidasePharmaceutical PreparationsQuinolinesQuinolones

Identifiers

PMID40569179
PMCPMC12451861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.