Trial reportActa dermato-venereologica2025
Comparison of Non-insulated Microneedle Fractional Radiofrequency and Ablative Fractional Carbon Dioxide Laser for the Treatment of Facial Atrophic Acne Scarring: A Pilot Randomized Split-face Clinical Study.
Trial report in Acta dermato-venereologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Laser, Microneedling, and Combination Therapies for Moderate to Severe Acne Atrophic Scars: A Systematic Review and Network Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Comparing fractional CO₂ laser and needling-based modalities in facial acne scar treatment: a comprehensive systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Fractional CO2 Laser Versus Micro Needling Radiofrequency for Post Acne Scarring: A Meta-Analysis of RCTs.Journal of cosmetic dermatology · 2026Pooled it
- Minimally invasive interventions for atrophic acne scars: a PubMed/PMC-based systematic evidence review and exploratory network meta-analysis toward phenotype-guided interpretation.Frontiers in surgery · 2026Pooled it
- Microneedling Radiofrequency Versus Fractional Laser for the Treatment of Acne Scars: A Systematic Review with Descriptive Quantitative Synthesis.Aesthetic plastic surgery · 2026Review
- Use of VISIA-CR Generation 5 in Aesthetic Skin Assessment: A Single-Case Review.Aesthetic surgery journal. Open forum · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A study was undertaken to compare the effectiveness and adverse effects of non-insulated microneedle fractional radiofrequency (NIMFRF) and ablative fractional carbon dioxide (AFCO2) laser on facial atrophic acne scarring in a randomized split-face model. Thirty subjects with facial atrophic acne scarring were enrolled. Each side of the face randomly received 1 session of NIMFRF or AFCO2 laser. Photographs were taken by VISIA Complexion Analysis System at baseline, 1 month, 2 months, and 6 months after treatments. Subjective evaluations included Échelle d'Évaluation Clinique des Cicatrices d'Acné (ECCA) score, global improve-ment, and self-satisfaction. Potential adverse effects were also recorded. Skin melanin index and ery-thema index were measured. NIMFRF and AFCO2 laser show-ed comparable efficacies on atrophic acne scarring (p > 0.05). ECCA scores decreased significantly at each follow-up visit, compared with baseline (p < 0.05). Approximate 95% of subjects achieved "satisfied" or "very satisfied" improvement. Pain was more obvious on the AFCO2 laser side. Significantly increased red area value, melanin index and erythema index levels were seen on the AFCO2 laser side at one month or 2 month, compared with the NIMFRF side (p < 0.05). NIMFRF has milder adverse effects with shorter recovery period than AFCO2 laser. NIMFRF may be preferable for some patients due to its favourable adverse effect profile.
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