5-Thiohistidine N-Acetyltransferase from Proteiniphilum Saccharofermentans.

Cangsong Liao, David Lim, Gladwin Suryatin Alim, Florian P Seebeck

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Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Cangsong LiaoDepartment of Chemistry, University of Basel, Mattenstrasse 22, Basel, 4002, Switzerland.

David LimDepartment of Chemistry, University of Basel, Mattenstrasse 22, Basel, 4002, Switzerland.

Gladwin Suryatin AlimDepartment of Chemistry, University of Basel, Mattenstrasse 22, Basel, 4002, Switzerland.

Florian P SeebeckDepartment of Chemistry, University of Basel, Mattenstrasse 22, Basel, 4002, Switzerland.ORCID https://orcid.org/0000-0003-4625-1369

Funding

Swiss National Science Foundation 51NF40-205608Swiss National Science Foundation IZLCZ0_206039

6 · The paper itself

Abstract

Ovothiol A is a 5-thiohistidine derivative biosynthesized by a broad range of prokaryotic and eukaryotic organisms. Its redox-active mercaptoimidazole side chain is believed to protect cells from oxidative stress. The three enzymes that produce ovothiol A from histidine, cysteine, and S-adenosyl methionine have been identified and characterized. In contrast, no enzymes are known that produce other 5-thiohistidine derivatives. Here, a small family of acetyl-coenzyme A-dependent transferases is described that produce N-acetyl-5-thiohistidine. The discovery of these enzymes from Proteiniphilum saccharofermentans and related Bacteroidota provides evidence that the 5-thiohistidine class may be structurally and functionally more diverse than previously thought.

Indexed as

AcetyltransferasesHistidineAcetyltransferasesHistidineacetyltransferasemarine natural productsovothiol

Identifiers

PMID40568848

DOI10.1002/cbic.202400439

PMCPMC12631010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.